The present study examines stroke patients* language abilities as well as the recruitment of additional brain areas in language use over time to compensate for stroke-induced language deficits.
ID
Source
Brief title
Condition
- Other condition
- Structural brain disorders
Synonym
Health condition
aphasia and language disorders through brain damage
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Main study parameter is the task-related brain activity measured with
electroencephalography and how it differs over time, together with patients*
functional communication and memory performance for the included behavioural
tasks.
Secondary outcome
To assess the effort that patients often experience in language use after
stroke lesions, measured by tracking the heart rate and skin conduction due to
sweat responses (GSR).
Background summary
Suffering from a stroke in the left hemisphere very often impairs patients*
language functions. Recent research suggests that, during recovery, additional
brain areas might be recruited to overcome deficits induced by the lesion.
However, the underlying processes of this neural recruitment and reorganization
of language functions in the brain are still largely unknown. The present study
will investigate the language-related recruitment and reorganization in the
brain at different time points after stroke. We will employ
electroencephalography combined with various language and memory tasks to gain
more insight into brain areas that are recruited for language functioning after
stroke lesions, and its effect on behavioural language performance.
Study objective
The present study examines stroke patients* language abilities as well as the
recruitment of additional brain areas in language use over time to compensate
for stroke-induced language deficits.
Study design
Longitudinal study at two time points to assess patients* memory and
communication abilities and language-related brain activity at approximately
two and seven months after stroke onset.
Study burden and risks
The current procedures of electroencephalography and magnetic resonance imaging
and experimental measures implicate minimal burden and insignificant risk to
participants. Patients do not directly benefit from their participation in
terms of therapeutic gain, but they do obtain extensive information about their
language and communicative abilities and change over time, which they
appreciate. Participants can withdraw from the study at any time point. The
findings of this study will yield further insights into the reorganization of
the language network after stroke and possibly aid to create more
individualized patient therapy and care.
Montessorilaan 3
Nijmegen 6525 HR
NL
Montessorilaan 3
Nijmegen 6525 HR
NL
Listed location countries
Age
Inclusion criteria
• Between 18 - 78 years of age
• Ischemic or haemorrhagic cerebral infarction
• Postonset of approx. 2 months (subacute stage) for session 1, and 7 months
(chronic stage) for session 2
• Native speaker of Dutch
• Pre-morbidly right handed
• Willingness and ability to give written informed consent and willingness and
ability to understand the nature and content, to participate and to comply with
the study requirements.
Exclusion criteria
• History of previous stroke
• Pre-existent cognitive problems
• Severe aphasia (unable to understand instructions or provide consent). This
will be predetermined by the referring neurologist or speech language
pathologist, according to their usual practice
• Use of psychotropic medication or recreational drugs
• Pregnancy
• Serious head trauma
• Neurological or psychiatric disorders (other than stroke or epilepsy as a
consequence of the stroke)
• Large or ferromagnetic metal parts in the head (except for a dental wire)
• Implanted cardiac pacemaker or neurostimulator
• Claustrophobia
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL72600.091.20 |