To investigate the functional implication of bacteria, cigarette smoke components and adipokines in HS pathology by analyzing the cytokine profiles and the antimicrobial peptide profiles in skin and peripheral blood samples of patients with HS and…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
De proefpersonen fungeren als de controle groep van patienten met de huidziekte hidradenitis suppurativa.
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is the difference of immune response to above
mentioned HS triggering factors, for example the cytokine/antimicrobial profile
after microbial exposure in HS patients compared to healthy controls.
Secondary outcome
N.A.
Background summary
HS is considered a complex disease involving several factors.The clinical
presentation of HS appears reminiscent of bacterial infection. However, the
role of these bacterial species is poorly understood and is far from resolved.
Other important associated factors are smoking and obesity.
In order to gain more insights into the pathogenesis of HS, especially the
interaction between commensal flora, cigarette smoke components, adipokines and
the immune system further exploration is required
Study objective
To investigate the functional implication of bacteria, cigarette smoke
components and adipokines in HS pathology by analyzing the cytokine profiles
and the antimicrobial peptide profiles in skin and peripheral blood samples of
patients with HS and healthy controls.
Study design
Exporative and experimental study
Study burden and risks
The subject will not directly benefit from this research, but participation
contributes to increase the knowledge about HS and subsequently improving
treatment and care.
Dr. Molewaterplein 40
Rotterdam 3015 GD
NL
Dr. Molewaterplein 40
Rotterdam 3015 GD
NL
Listed location countries
Age
Inclusion criteria
Inclusion criteria cases * HS patients
- Participating in HiScreen Biobank
- Informed consent available for blood samples
Inclusion criteria controls
- Adult (> 18 years old) patients not suffering from HS.
- Competent and willing to provide informed consent.
Exclusion criteria
Exclusion criteria HS patients
- <18 years of age
- use of systemic or local antibiotics in the past 2 weeks
- use of any other medication potentially affecting the cytokine/antimicrobial
profiles
-
Exclusion criteria controls
- <18 years of age
- known with hidradenitis suppurativa
- use of systemic and local antibiotics in the past 2 weeks
- use of any other medication potentially affecting the cytokine/antimicrobial
profiles
- pregnant women
Exclusion criteria controls
- <18 years of age
- known with hidradenitis suppurativa
- use of systemic and or local antibiotics in the past 2 weeks
- use of any other medication potentially affecting the cytokine/antimicrobial
profiles
- no relatives with HS
- pregnant women
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL71699.078.19 |