Primary Objective: Validation of T1rho&T2mapping in healthy volunteers and patients with an OCD of the talusSecondary objective: To quantify T1rho & T2 mapping in patients with osteochondrial defects against healthy volunteers with 3T MRI…
ID
Source
Brief title
Condition
- Joint disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary outcomes are the T1rho relaxation times of healthy volunteers and
patients at two different spinlock frequencies.
Secondary outcome
Secondary outcomes are the T2 relaxation times of healthy and patients and
correlate these times to the T1rho times for complementary
Background summary
Osteochondral defects (OCD) of the talus are common injuries of the ankle. This
injury is mostly caused by a single or multiple trauma to the ankle and can
cause deep ankle pain during weight bearing movements. If the defect remains
untreated, further deterioration of the joint can occur and even osteoarthritis
of the ankle. Often surgery is needed to relieve of symptoms.
Current diagnosis en preoperative planning consists of radiography, MRI and CT.
To acquire a better picture of the extent of cartilage damage, various
techniques exist to assess the compositional or biochemical properties of the
cartilage tissue with MRI. One of these techniques is T1rho. This technique has
shown to be sensitive for glycosaminoglycans and proteoglycans content.
Previous research with T1rho have been done for applications in the knee for
osteoarthritis and cartilage repair with promising results. Another similar
technique will also be investigated, namely T2, this has shown to be more
specific for collagen content and orientation. The application of T1rho has not
yet been investigated in the ankle and this study shall research the feasiblity
of T1rho for identifying and quantifying cartilage damage in the ankle.
Study objective
Primary Objective: Validation of T1rho&T2mapping in healthy volunteers and
patients with an OCD of the talus
Secondary objective: To quantify T1rho & T2 mapping in patients with
osteochondrial defects against healthy volunteers with 3T MRI based on talus
cartilage.
Tertiary objective: To gain insight into the clinical application of T1rho and
T2 for identifying and quantifying cartilage damage.
Study design
Patients with an osteochondral defect of the ankle will be asked preoperatively
to participate in the study. healthy volunteers will be recruited through a
pamphlet. There will be no follow-up.
Within 19 months we expect to have recruited and scanned the subjects as well
as analyzed the obtained data.
Study burden and risks
Risks for the subjects undergoing a MRI examination are minimal, provided
precautions have been made to prevent examining individuals with
contraindications. For this purpose, the routine MRI contra indications form of
the AMC will be used. There is no direct group related benefit.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
informed consent, no ankle pain (healthy), diagnosed OCD (patient), BMI under
30,
Exclusion criteria
suspicion of pregnancy, metallic objects inside subject body (like pacemakers)
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL59024.018.16 |