The objective of this study is to elucidate unique and shared impairments across a broad range of social cognition tasks (at the behavioral, neuropsychological, and neurophysiological level by means of EEG recordings) related to subdimensions of…
ID
Source
Brief title
Condition
- Other condition
- Cognitive and attention disorders and disturbances
Synonym
Health condition
disruptief gedrag en agressie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Behavioral: Empathy (score on EMQUE-CA questionnaire)
Cognitive: Working memory (SWM accuracy)
QEEG: resting state frontal alpha asymmetry
ERPS: N170 during the emotion recognition task
Secondary outcome
Behavioral: Questionnaires on temperamental factors, emotional regulation,
social reward, normative beliefs about aggression, environmental sensitivity,
autism traits, sensory processing, strengths and difficulties
Cognitive: Accuracy and reaction times on tasks measuring reaction time, visual
matching, sustained attention, number of stages completed on the planning
task, and accuracy and reaction times on the EEG tasks measuring emotion
recognition, emotional interference, social approach/avoidance and theory of
mind
QEEG: resting state frontal theta activity and theta/beta ratio
ERPS: N170 and LPP during emotional interference, social approach-avoidance
and theory of mind
Background summary
Antisocial, rule-breaking, and/or disruptive and aggressive behaviors are among
the most frequent reasons for referral to child and adolescent mental health
services and associated with poor long-term outcomes (such as antisocial
personality disorder, criminality, employment or health problems). A major
hurdle for finding effective approaches to diagnosis, prevention, and treatment
is the heterogeneity of these behaviors. Social cognition is crucial to
appropriate interpersonal functioning and may therefore provide valuable
information about the processes involved in behavior problems as well as
possible targets for intervention. However, currently, impairments in social
cognition across the heterogeneous population of youth with clinically
significant behavioral problems have not been fully elucidated, illustrating
the need for studies incorporating multiple aspects of social cognition, on the
behavioral, neuropsychological, and neurophysiological level, in a diverse
population of youth with behavioral problems.
Study objective
The objective of this study is to elucidate unique and shared impairments
across a broad range of social cognition tasks (at the behavioral,
neuropsychological, and neurophysiological level by means of EEG recordings)
related to subdimensions of behavior in youth with behavioral problems as
compared to healthy controls, to improve the subtyping of these behaviors and
possibly identify targets for intervention.
Study design
The current study will employ an observational case-control design. This allows
for examining associations of neurophysiological and behavioral responses with
behaviors of interest, as well as deviations from neurotypical functioning.
Study burden and risks
The burden of this study entails one research visit of about 5 hours with a
total time investment about 6 hours for the participating adolescent and about
2 hours for one of the parents. During the visit, a clinical interview will be
conducted with the adolescent and their parent(s) separately (each 1 hour). The
participant will complete a neuropsychological test battery and IQ screening
taking around 60 min. In addition, an EEG recording will be done (approximately
25 min preparation and 83 min of recording, and around 10-15 min for breaks in
between the tasks), where we will record resting state activity and
task-related activity during which the participant has to complete additional
neuropsychological tasks. The parent(s) will be able to complete all
questionnaires (approximately 45 min) at home and/or during the research visit,
whereas the participant is asked to fill out the questionnaires (approximately
45 min) at home, prior to the research visit. The risks of participating in
this study are negligible and the possible physical and psychological
discomfort mild. The inclusion of minors with behavioral problems is needed to
elucidate underlying mechanisms of social impairment related to behavioral
problems that may emerge or may be strongest during adolescence, a period with
a marked importance of social interactions with the peer group, to identify
possible treatment targets and develop strategies to prevent long-term negative
outcomes.
Lübeckweg 2
Groningen 9723 HE
NL
Lübeckweg 2
Groningen 9723 HE
NL
Listed location countries
Age
Inclusion criteria
• Aged 12-17 at inclusion
• Ability to comprehend and speak Dutch
• Deemed reliable and compliant with the study protocol
• Be right-handed
Those with behavioral problems must also meet the additional criteria:
• Presence of clinically significant behavioral problems as defined by T > 63
on the externalizing subscale of the Child Behavior Checklist (CBCL) or the
Youth Self-Report (YSR). The externalizing dimension of the CBCL includes the
rule-breaking behavior and aggressive behavior syndrome subscales (not ADHD).
To ensure we also include youth with more severe behavioral (rule-breaking)
problems, we aim to have at least 50% of participants with clinically
significant behavioral problems scoring T > 70 on the rule-breaking subscale of
the CBCL and/or YSR.
• At least 2 weeks of stable treatment /medication
Exclusion criteria
• Intellectual disability (IQ < 70) based on available IQ measure or the
clinical opinion of the
investigator (taking into account relevant psychosocial information,
e.g. educational level)
• History of or current head injury
• History of neurological disorders
• A known lifetime history of epilepsy
• A known lifetime history of psychotic and bipolar disorder, or severe current
mental state according to the impression of the researcher (such as depression)
Potential healthy control subjects who meet any of the following additional
criteria will be excluded from participation in this study if they have:
• A parent or self-reported diagnosis of a psychiatric disorder
• T-scores in the borderline or clinical range on the externalizing (T >= 60),
rule-breaking (T >= 65) or aggressive behavior (T >= 65) subscales of the CBCL or
YSR.
• No stable use of psychotropic medication in the past four weeks
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL74687.042.20 |