To gain a better understanding on common and diverse mechanisms of stress-related and developmental disorders at different genetic, cognitive, behavioral and neurobiological levels in an ultimate attempt to redefine psychiatric symptomatology by…
ID
Source
Brief title
Condition
- Psychiatric disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Socio-demographics
Descriptive psychopathology, somatic status and treatment history
Biological measures, such as cortisol levels
Neuropsychology
Genetics
Gut microbiome
Neuroimaging
Secondary outcome
na
Background summary
To integrate preclinical and clinical methodologies to assess and validate the
relevance of common epigenetic mechanisms, stressregulators and their markers
on neuroplasticity, neural functional connectivity and behavior in patients
affected by stress-related and neurodevelopmental mental disorders.
Study objective
To gain a better understanding on common and diverse mechanisms of
stress-related and developmental disorders at different genetic, cognitive,
behavioral and neurobiological levels in an ultimate attempt to redefine
psychiatric symptomatology by these means.
Study design
Observational cross-sectional study. We include four follow-up measure (online)
during the Covid-19 crisis to assess resilience and symptom developmen.
Study burden and risks
In this observational study, we ask participants to fill out questionnaires,
undergo neuropsychological tests, collect a faeces sample en undergo a
functional MRI scan. These methods can be regarded as safe and are frequently
used in scientific research.
The effects of the stress induction for the MRI scan are temporary.
Reinier Postlaan 10
Nijmegen 6525GC
NL
Reinier Postlaan 10
Nijmegen 6525GC
NL
Listed location countries
Age
Inclusion criteria
Patients:
- Adult (age>17) in- and outpatients at the Department of Psychiatry of the
Radboudumc
- with a neurodevelopmental disorder: Autism Spectrum Disorder and/ or
Attention-Deficit/ Hyperactivity Disorder
- and/ or a stress-related disorder: mood disorder, addiction disorder, mood
disorders with somatic comorbidity.Healthy controls:
- Adult (age >17) individuals
- without a lifetime history of psychiatric disorders.
Exclusion criteria
Patients:
- Full scale IQ estimate < 70
- Diseases of the central nervous system resulting in (permanent) sensorimotor
and/or (neuro)cognitive impairments
- Current psychosis
- Inadequate command of the Dutch language
- Mentally incompetent to sign informed consent
Additional criteria for control participants:
- Neurological disorders of the central nervous system
- Fifteen or more units of alcohol per week
- Recreational drug use of once or more per week
- Benzodiazepine use of once or more per week
- Malignancies
- Rare, chronic somatic disorders, for which matching will not be possible
- First degree relatives with severe psychiatric disorders
Exclusion criteria specifically for the MRI section of the MIND-Set study:
- Metal objects in the body (excluding dental fillings)
- Jewelry or peircings that cannot be removed
- Brain surgery
- Epilepsy
- Claustrophobia
- Pregnancy
- Ferromagnetic implants or pacemakers
- Inability to lie still for one hour psych
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL55618.091.15 |