The primary objective of this research project is to further validate the fatigue resistance test by comparing muscle endurance outcomes obtained by the Martin Vigorimeter and the Jamar Dynamometer in subjects of different ages and clinical…
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- Other condition
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Health condition
er wordt geen aandoening bestudeerd, het betreft gezonde proefpersonen
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Fatigue resistance:
assessed by both the Martin Vigorimeter and the JAMAR dynamometer in a random
order (see appendix 1 for detailed description). Both tests will be performed
at the same day with at least 1 hour interval. In a subgroup of participants
the fatigue resistance test will be performed by a modified digital manometer
and Dynamometer G200 system, and with simultaneous synchronized sEMG recording
of the fore-arm muscle (all connected to a MPAQ universal amplifier, Maastricht
Instruments) in order to appraise muscle fatigue curves and related muscle
activation. Area under the curve and other derived muscle endurance parameters
are calculated as described previously.
Secondary outcome
Figures refer to reference list in the protocol.
Explanatory outcomes
Hand function & pain: Perceived pain in the hands directly following the
fatigue resistance test (Numeric Rating Scale), Hand
function(Australian/Canadian Hand Osteoarthritis Index) (17), presence/number
of phalangeal nodules (using standard photographic registration and visual
counting). In a subgroup of participants a standard ultrasonographic assessment
of the hands will be performed in order to assess the degree of osteoarthritic
lesions (18).
Sarcopenia assessment according to European consensus criteria (19) including
physical functioning (Short Physical Performance Battery (20), Timed Up-and-Go
test (21), 2 minutes step test (22), flexicurve ruler (23) and body composition
(Bio-electrical Impedance, Quadscan4000, Bodystat, Ashhurst, New Zealand) (24).
Self-perceived fatigue & physical activity: MOB-Tiredness scale (25),
Multidimensional Fatigue Inventory (26) and Yale Physical Activity
Questionnaire (27).
General health and quality of life: co-morbidity & medication use using
self-report questionnaires; Medical Outcome Study (MOS) Short-form (28);
cognitive functioning (MMSE (16); dependency for activities of daily life
(basic (29) & instrumental (30) ADL)
Inflammatory parameters: serum obtained from non-fasting venepuncture, stored
at -80°C for ulterior determination of circulating markers of inflammation
(including IL-6, sTNFR1, IL-10, IL-1RA, IL-8, HSP70) as described previously
(31,10).
Background summary
In a series of 10 original studies (references 1-10, see protocol) we have
introduced, refined and validated a new assessment method for muscle fatigue
resistance as a direct and objective outcome parameter of the exhaustion
component of Frailty in elderly persons. Our test is now internationally
accepted and several researchers as well as clinicians are using it. The
fatigue resistance test has been validated for the Martin Vigorimeter (KLS
Martin Group, Tuttlingen, Germany), a device to measure grip strength
consisting in a rubber bulb connected to a manometer. Since this device is very
comfortable and allows performing a dynamic contraction (the rubber bulb is
compressible), it is highly suitable to assess sustained maximal contractions
in elderly subjects. However, many researchers and clinicians are using the
Jamar dynamometer (Sammons Preston, Rolyon, Bolingbrook, IL), a device designed
to measure static grip strength (see figure 1B). Grip strength measures
obtained by the Martin Vigorimeter have been shown to be well correlated with
those obtained with the Jamar dynamometer. Though, to date, no data regarding
the fatigue resistance test measured with the Jamar dynamometer are available,
thus limiting the implementation of the fatigue resistance test. Validation of
the fatigue resistance test with the Jamar dynamometer would improve its
implementation in daily practice.
Study objective
The primary objective of this research project is to further validate the
fatigue resistance test by comparing muscle endurance outcomes obtained by the
Martin Vigorimeter and the Jamar Dynamometer in subjects of different ages and
clinical condition.
A second objective is to propose normative data for both systems that can be
used for clinical interpretation of the muscle endurance scores.
A third objective is to appraise the importance of clinical correlates in the
interpretation of muscle fatigue resistance.
Study design
Cross sectional study, explorative
Study burden and risks
The subjects will be assessed only once, during 1 h 15 min with 1 hour interval
between the fatigue resistance tests. During the fatigue resistance test only
the dominant hand is tested. The subject is asked to squeeze the large bulb of
the Martin Vigorimeter / the handle of the JAMAR dynamometer twice. First as
hard as possible and a second time as long as possible untill force has dropped
below 50%. This test as well as the other evaluations do not influence
subject's integrity. They are commonly used diagnostic tests in physical
therapists' daily practice to evaluate muscle function and physical
performance. Prior to the assessment the investigators are trained to
standardize the protocol. During the assessments an observator will be present
to control the procedure.
Blood sampling (20 ml. per sample) normally is innocent, but sometimes is
accompanied by minor inconveniences such as pain during or after the puncture,
or a bruise after sampling.
Softwareweg 5
Amersfoort 3821 BN
NL
Softwareweg 5
Amersfoort 3821 BN
NL
Listed location countries
Age
Inclusion criteria
Young, healthy subjects aged 18-30 years: completely healthy, no medication
use, no impairments interfering with muscle fatigue resistance test, normal
physical activity (i.e. at least 150 minutes/week at moderate intensity but no
competitive sports).
Community-dwelling subjects aged >30years: living independently in the
community, no functional disability of the dominant upper extremity
(paresis/paralysis, tremor or recent surgery), normal cognitive functioning
(Mini-Mental State Examination [MMSE] score >23/3016).
Exclusion criteria
Pregnant women are excluded.
Acute or uncontrolled conditions, chronic inflammatory pathology and/or central
nervous disease (e.g. Parkinson*s disease, Multiple Sclerosis, Cerebro-Vascular
Accident).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL51425.096.14 |