To investigate the timing and coordination of speech articulation and its relation to speech disorders of people who have been treated for oral cancer with a major resec-tion. This information will lead to a better understanding of articulation and…
ID
Source
Brief title
Condition
- Head and neck therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Displacement of the tongue tip, the tongue body, the lips and the jaw at
consonant and vowel targets
- Velocity of tongue, of the tongue tip, the tongue body, the lips, and the jaw
at key landmarks of speech gestures.
- Duration of speech gestures produced with the tongue tip, the tongue body,
the lips and the jaw.
- Speech rate (syllables/min and words/min)
Secondary outcome
- Acoustic measures of speech
- Models to link articulation and speech, both speech synthesis from EMA, and
EMA from speech (machine learning)
- Changes in the variability and complexity of articulators* movement under
masked auditory feedback compared to normal feedback
Background summary
People treated for oral cancer with a major resection procedure often develop
problems with swallowing and articulation. The deviant articulation affects
speech, complicates communication, and has a negative effect on the quality of
life of patients. Currently, the available information on the effects of oral
cancer treatment on speech articulation is rather scarce, especially with
respect to the changes and adaptations in articulatory processes in these
speakers. The proposed research will shed more light on this issue and will
lead ultimately to a better understanding of the anatomical and physiological
basis of the disordered speech in oral cancer patients. In turn, this
information will be-come available to clinicians and speech therapists who will
be able to minimise negative effects of treatment and improve therapies after
treatment.
Study objective
To investigate the timing and coordination of speech articulation and its
relation to speech disorders of people who have been treated for oral cancer
with a major resec-tion. This information will lead to a better understanding
of articulation and articulation related speech problems after oral cancer and
will ultimately aid speech therapy and improve the information and consultation
of these patients.
Study design
Subjects will perform several speech tasks. Some of the speech tasks will be
carried out while the participant is wearing earphones through which pink noise
is distributed (at a comfortable volume). During these tasks, articulatory
trajectories will be recorded using electromagnetic articulography (EMA). The
data from the oral cancer patients will be compared to EMA and speech data from
non-speech disturbed controls.
Study burden and risks
No known risks or benefits are associated with participating in this study.
Hanzeplein 1
Groningen 9713GZ
NL
Hanzeplein 1
Groningen 9713GZ
NL
Listed location countries
Age
Inclusion criteria
• At least 18 years of age and able to make an informed consent
• Native speaker of Dutch
• Diagnosed with oral tumors and having had a major surgical resection of a TNM
stage T3 or T4, where parts of the tongue or jaw have been removed and perhaps
replaced by other tissue at least 12 months before (patient subject) or a
volunteer without disturbed speech.
Exclusion criteria
• Recurrence of disease
• History of neurological or psychological disorders
• Self-reported signs of depression
• Stuttering or other pre-existing speech and language problems
• Anatomy that prevents attaching sensors to the tongue (i.e., trismus or
tongue immobility)
• Problems with sight or hearing that impede reading or understanding
instructions. When glasses or a hearing aid resolve these problems, there is no
impediment to participation.
• Non removable metal on, in or close to the head (e.g., piercings, dental
braces, medical devices such as deep brain stimulation electrodes) or medical
devices (e.g., a pacemaker) incompatible to electromagnetic fields.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL76137.042.20 |