Our primary objective is to investigate the relation between atypical IMP and SINDA scores in infancy and symptoms of DCD at 4-5 years of age measured with the Movement Assessment Battery for Children - 2nd edition. The relation will also be…
ID
Source
Brief title
Condition
- Neurological disorders NEC
- Developmental disorders NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Our parameters are scores obtained through assessments and questionnaires to
assess symptoms of the previous mentioned developmental disorders.
Our main study parameter is the score on the *Movement Assessment Battery for
Children - 2nd edition* (MABC-2); a valid and reliable motor assessment for
children aged 3 to 16 years which is developed to assess DCD. The scores of the
MABC-2 are dichotomized as *at risk of DCD* (<=16th percentile) or not.
Secondary outcome
- The Developmental Coordination Disorder Questionnaire-revised (DCDQ): to
assist in the identification of DCD in children.
- The Conners* Rating Scale-Revised (CRS-R) for parents and teachers: to assess
ADHD and most common co-morbid problems as reported by teachers, parents or
other caregivers.
- Wechsler Preschool and Primary Scale of Intelligence - IV (WPPSI-IV NL): a
test of intellectual ability for children aged 2.5 to 7 years.
- Social Responsiveness Scale (SRS-2): this widely used scale identifies social
impairment associated with ASD and quantifies its severity.
- The Sensory Profile (SP-NL): a measure of children*s responses to sensory
events in daily life to assess sensory stimulus information processing
difficulties.
- Minor Neurological Dysfunction (MND) assessment: neurological age-specific
examination to detect minor neurological dysfunction.
- Strengths and Difficulties Questionnaire (SDQ) this short behavioural
screening instrument is suitable for children aged 2 to 17 years old and aims
to identify psychosocial problems in children.
Other study parameters are:
- All relevant information obtained during the earlier stages of the IMP-SINDA
study or BIRD I study concerning pre-, peri- and neonatal factors, and
behaviour and developmental factors assessed with the online questionnaire in
BIRD 1. Relevant information includes the general questionnaire on presence of
illnesses, medication use and visual and auditory problems, known developmental
problems, current school of the children, socio-economic background,
psychiatric and developmental disorders in the parents.
Background summary
There is an evident delay between parents* first concerns and confirmation of a
neurodevelopmental disorder, such as autism spectrum disorder (ASD), attention
deficit hyperactivity disorder (ADHD), developmental coordination disorder
(DCD), and intellectual disability. This is due to a lack of knowledge on signs
in infancy of these disorders. As a consequence, concerns of parents remain
unheard and interventions start late. In our previous study (IMP-SINDA norms
study) 1700 infants aged 2-18 months were assessed with two new infant
neurodevelopmental assessments: the Infant Motor Profile (IMP) and the
Standardized Infant NeuroDevelopmental Assessment (SINDA). In the current study
we will continue in the same cohort of children, and investigate the
association between their neurodevelopmental condition at age 2-18 months as
measured with IMP and SINDA with their neurodevelopmental, emotional, and
behavioural functioning when they are 4-5 years of age.
We expect that atypical IMP-SINDA scores in infancy are associated with
symptoms of developmental disorders at 4-5 years of age.
Study objective
Our primary objective is to investigate the relation between atypical IMP and
SINDA scores in infancy and symptoms of DCD at 4-5 years of age measured with
the Movement Assessment Battery for Children - 2nd edition. The relation will
also be expressed in terms of predictive values (sensitivity, specificity,
negative and positive predictive values.
Secondary objectives:
- To investigate the relation between atypical IMP and SINDA scores in infancy
and symptoms of ADHD at 4-5 years of age.
- To investigate the relation between atypical IMP and SINDA scores in infancy
and symptoms of ASD at 4-5 years of age.
- To investigate the relation between atypical IMP and SINDA scores in infancy
and intellectual disability at 4-5 years of age.
- To investigate the relation between atypical IMP and SINDA scores in infancy
and sensory stimulus information processing difficulties at 4-5 years of age.
Study design
Nested case-control study, drawn from the population of a cross-sectional study
in the general population.
Study burden and risks
The children will be assessed once, at the Child-lab at the Institute for
Developmental Neurology (UMCG) or at the child*s home. The assessment has the
form of play. Children mostly enjoy the assessments, but it may happen that a
child is anxious or is not in the mood for an assessment. If the child shows
signs of protest, the assessment will be stopped. It is discussed with the
parents whether the assessment will be resumed or it may be rescheduled to a
later point in time or will be cancelled. During the assessment of the child,
parents will fill out a questionnaire on signs of developmental disorders (60
min). The entire assessment will take about 90 minutes. There are no risks
associated with participation. The benefit of the study is that it will result
in knowledge about neurodevelopmental signs of developmental disorders and
therefore enable early detection and intervention of these disorders.
Hanzeplein 1 Hanzeplein 1
Groningen 9713 GZ
NL
Hanzeplein 1 Hanzeplein 1
Groningen 9713 GZ
NL
Listed location countries
Age
Inclusion criteria
- Subject has participated in the IMP-SINDA norms study (METc 2016.294)
- Age at inclusion between 4 and 5.5 years
Exclusion criteria
There are no criteria to exclude a potential subject from participation in this
study.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL75617.042.20 |