To investigate the impact of different types of proteins on muscle damage upon an endurance exercise bout in elderly.
ID
Source
Brief title
Condition
- Muscle disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome is CK-level in blood after a prolonged exercise bout.
Secondary outcome
Secondary study parameter are muscle strength, muscle mass and muscle pain.
Background summary
Rationale: Loss of skeletal muscle mass and strength is a consequence of aging.
Especially essential amino acids are key nutrients for muscle health in elderly
adults. A protein intake of 1.2-1.5 g/kg/day is recommended for elderly, but
more than half of the elderly do not reach this daily protein intake
recommendation. Until today, humans consume more proteins from animal sources
compared to plant-based sources. Though, the consumption of animal-based
proteins in the aging population brings disadvantages such as an increased risk
for cardiovascular disease and various cancers. Because of that, it seems more
advisable to increase protein intake of elderly with plant-based proteins. In
this study, we want to investigate the effect of various types of a plant-based
protein on aging muscles.
Study objective
To investigate the impact of different types of proteins on muscle damage upon
an endurance exercise bout in elderly.
Study design
This explorative study is a double-blind randomized controlled trial. For 2
subsequent weeks, the effects of a daily 1) plant-based protein, 2) whey
protein, or 3) a placebo supplementation, on muscle damage, muscle mass and
muscle strength will be investigated.
Intervention
The subjects will be randomly assigned to a protein or placebo supplement
group. It will be consumed as a drink or smoothie. Upon completion of the
2-week supplement consumption, subjects will be asked to perform once an
endurance exercise bout of walking 30 kilometres.
Study burden and risks
The risks involved in participating in this experiment are minimal. The protein
supplements provided are generally available existing products with no adverse
effects. Protein and placebo supplements will be produced under Good
Manufacturing Practices in certified facilities and using approved and
commercially available ingredients.
Philips van Leydenlaan 15
Nijmegen 6525EX
NL
Philips van Leydenlaan 15
Nijmegen 6525EX
NL
Listed location countries
Age
Inclusion criteria
- Aged 60 and higher
- Able to walk 20-30km in 1 day
- able to understand and follow the study procedures
Exclusion criteria
- Diabetes
- Lactose intolerance or milk allergy
- BMI >30kg/m2
- Diagnosed with COPD
- Diagnosed with kidney failure
- Diagnosed with a bowel disease that influences protein uptake, such as
inflammatory bowel disease or Crohn's disease.
- Consumption of other freely available protein supplements on their own during
the inclusion period and the study period of about 1 month.
- If the subject intends to perform additional prolonged exercise bouts in the
4 days before and the 4 days after the studied exercise bout of walking 20-30
kilometres.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL77522.091.21 |
| OMON | NL-OMON24234 |