We aim to illustrate the relationship between early-life-adversity and emotional memory performance, and whether schema related neural activity during encoding and retrieval will contribute to the negative memory biases.
ID
Source
Brief title
Condition
- Other condition
- Mood disorders and disturbances NEC
Synonym
Health condition
early life adversity
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter is neural mechanism underlying the relationship
between early-life-adversity and emotional schema memory effect. Therefore, a
within-subject design with an fMRI measurement is conducted to investigate
emotional schema memory effect and its neural correlates. Here we define
emotional schema memory effect as: when a negative schema is activated by music
mood induction procedures, the participants will have enhanced memory
performance for negative stimuli at the behavioural level. At the neural level,
we will analyze the encoding related activity particularly subsequent memory
effect (SME) and spatial pattern (representational similarity) in the medial
prefrontal cortex (mPFC) and hippocampus.
Secondary outcome
Secondary study parameters are the measurements for attention and emotion bias
(skin conductance recodings, self reports and eye-tracking data), which will
control the specificity of the bias. It might be possible that memory bias
effects are caused by biases in attention and emotion, therefore it is
important for future use of the results to properly control by these
parameters.
Background summary
Negative memory bias (the selective enhancement of negative memory) plays an
important role in the onset and maintenance of depression. Early-life-adversity
is one of the main risk factors of negative memory bias formation on the one
hand and depression on the other hand. In this study, we will focus on the
neural mechanism of negative memory bias from the perspective of
early-life-adversity and depression. Based on previous research showing the
facilitation of prior knowledge (schema) to new information acquisition and the
potential effect of emotional schema, we will test whether higher
early-life-adversity and subclinical affective symptoms will be related to
higher negative memory bias especially when a negative schema is activated.
Study objective
We aim to illustrate the relationship between early-life-adversity and
emotional memory performance, and whether schema related neural activity during
encoding and retrieval will contribute to the negative memory biases.
Study design
Observational study
Study burden and risks
Participants anonymously fill in the online questionnaires for a general
screening of early-life-adversity and depression. Based on this, eligible
participants are provided with study information and invited anonymously over
the survey system to Donders Center. After sufficient consideration and
explanation, they will sign the informed consent form if they choose to
participant in based on fully understanding. Then a detailed evaluation by the
Maltreatment and Abuse Chronology of Exposure (MACE) Scale and Beck Depression
lnventory-II (BDI-II) will be administrated. After this first questionnaire
screening session, participants are invited to take part in the MRI session,
where they will firstly view emotional pictures with and without schema
activation and do the recognition memory tests later.
Filling in the MACE and BDI-II in an unsupervised manner is not known to create
any risks to the participant. This data will be strictly protected in
accordance with the Dutch Personal Data Protection Act (WBP). Participants will
indicate on the consent form whether they agree with the later use of this
data, and hold the right of revoking at any time they want. MRI is a
non-invasive imaging technique. Participation in an MRI investigation is not
associated with any risks or long-term consequences for the participant. The
threatening context applied during MRI scanning and MRI investigation itself
might cause discomfort for the participant. Viewing pictures and making the
judgements on old/new may cause participants* tiredness. Participants are
informed about their right to stop the experiment at any time if they feel too
burdened. Since we want to explore the relationship between
early-life-adversity, depression and negative schema effect, a broader range
early-life-adversity and depression level is necessary for data analysis. It is
important to note that we will only include healthy individuals with
sub-clinical levels of depression. We will check for clinically relevant signs
of mental disorders when participant present strongly elevated self-ratings of
depression (BDI-II score > 20) and also childhood adversity (MACE>51).
Kapittelweg 29
Nijmegen 6526EN
NL
Kapittelweg 29
Nijmegen 6526EN
NL
Listed location countries
Age
Inclusion criteria
Normal or corrected-to-normal vision
Normal uncorrected or corrected-to-normal hearing
Willingness and ability to understand nature and content of the study
Ability to participate and comply with study requirements
Fluent in Dutch (>= B1 level)
Exclusion criteria
History of or current or previous neurological or psychiatric disorders (except
depression), or other relevant medical history, cognitive impairments
History of or current brain surgery or epilepsy
Pregnancy
MRI incompatibility (unremovable metal parts in upper body [plates, screws,
serre-fines, dental plates (pontics), metal splinters, piercings or medicinal
plasters), active implant [e.g. Pacemaker, neuro stimulator, insulin pump
and/or hearing aid], head operation, epilepsy, claustrophobia).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL81194.091.22 |