Smart device for clinically validated MOVEment assessment and monitoring at home and in the clinic (SMOVE) PART 2: Algorithm validation in Parkinson patients

Monitoring and quantifying physical activity and their intensity patterns gives
general insight into the intensity and type of activity people perform. The
qualitative aspects of movements (how are movements performed) can provide
detailed knowledge of specific biomarkers related to motor impairments. These
assessments are typically done in the controlled environment of the lab or
clinic. However, laboratory-based analysis may not fully reflect individual
free-living motor capabilities while monitoring people in their home
environment, can provide more valid information about a person*s functioning,
and allows monitoring of interventions and severity of disease outside the
clinic. Wearable sensors, like (3D) accelerometers, gyroscopes and surface
electromyography make home monitoring possible. In the SMOVE project (Smart
device for clinically validated MOVEment assessment and monitoring at home and
in the clinic; INTERREG EU financed),
we aim to develop a *hybrid sensor system* for automatic, continuous monitoring
of specific movement features in the laboratory and especially in free
living-like conditions.

We here validate the algorithms for movement analysis that were developed
previously in healthy participants (METc 2019.542; regarding quantitative
aspects of movement) and that were derived from a review of the literature
(regarding qualitative aspects of movement in patients), in a small study with
one patient group.

This cross-sectional, observational study concerns a study in 10 adult patients
with Parkinson*s disease (PD). In 5 patients, different types of movement will
be assessed during scripted as well as daily life tasks in and around the
laboratory to simulate various free-living conditions during approximately two
hours. Their movements will be videotaped. In another 5 patients, movement will
be assessed during daily living in the patient*s home environment during
approximately 7 hours. All participants will wear eight small light-weight
inertial measurement units at different locations on their body during
measurement. We will first classify movements and then determine quantitative
(intensity) and qualitative (gait, tremor, bradykinesia-related)
characteristics of movement.

There are no risks or benefits, and the burden is limited to the time invested
in the test (approximately 2 hours for patients measured in the lab and
approximately 7 hours for patients measured at home). Video will be recorded of
the participants throughout the experiment in the lab; faces will be blurred in
the post-processing.*