The iBerry Study 3.0 - Research on social, psychological and physical development in youth.

In August 2014, the iBerry Study started the first phase of a longitudinal
study on the development of psychiatric disorders in cooperation with the
Center for Youth and Families in the Rijnmond region (MEC-2014-416). In high
school, adolescents aged 12-14 years were screened on emotional and behavioral
problems as part of standard preventive youth health care. This has resulted in
a selection of adolescents in which adolescents with a problem score in the top
15% scores of emotional and behavioral problems were overrepresented. In the
second phase of the iBerry Study, selected adolescents were invited for their
first visit at the research center as part of the iBerry Study baseline
measurement (MEC-2015-007).
A total of 1022 adolescents enrolled in the study, of which 728 with the
highest problem scores and 294 randomly selected from the other adolescents.
This method generated sufficient power to investigate various biological,
psychological and social factors that contribute to the transition to (adult)
psychiatric disorders.


Selected adolescents and their parents were invited for a first visit, the
baseline measurement, to the iBerry research center in the second phase of the
study (MEC-2015-007). Data on emotional and behavioral problems, physical
health, lifestyle, family functioning, genetic profiles, sociodemographic
background, use of care and cognitive profile were collected by administering
interviews, questionnaires, neuropsychological tasks and physical measurements.
The baseline measurement was completed in 2019, resulting in a total cohort of
1022 adolescents.


The first follow-up measurement started in March 2019 (T1). Part of the
instruments used at the baseline measurement are repeated and additional
age-appropriate instruments were added. Study details are described in the
study protocol, MEC-2018-14472.

The current research protocol concerns the second follow-up measurement in the
second phase of the iBerry Study (T2). This measurement will take place two to
three years after the first follow-up measurement. The objective is to further
identify key factors in the course of (sub)clinical psychiatric symptoms. By
accurately mapping and monitoring (sub)clinical psychiatric symptoms, the
iBerry Study aims to provide significant insight in the background and course
of psychiatric disorders and to contribute to the development of preventive
interventions.

The iBerry Study has two main study objectives:
1. Descibing long-term prognosis of subclinical symptoms in terms of course
(transition to several psychiatric disorders, chronicity, recurrence,
comorbidiy) and public health consequences (disability, costs)
2. Examining genetic, biological and psychosocial determinants of the
transition from subclinical symtoms to psychiatric disorders.

The iBerry Study is a prospective observational study.

Assessments in participating young adults consist of measurements by
questionnaires, interviews and physical measurements (e.g. length, weight,
blood pressure, actigraphy). The total time load of the visit will take no more
than 3,5 hours. The actigraphy has an additional time load of 1 hour, divided
over 9 days.
Assessments in participating parents/caretakers consist of measurements by
questionnaires, interviews and physical measurements (e.g. length, weight,
blood pressure). The total time load of the visit will take no more than 3,5
hours.
All measurements are performed by trained researchers.

Participants do not directly benefit from participation in the iBerry Study
3.0, apart from gratification by gift vouchers. Participation may indirectly
lead to early detection of serious psychiatric conditions, for which effective
treatment is availlable. When participants are diagnosed with serious
psychiatric conditions with possible danger for themselves or others, they will
be informed and advised to visit their general practitioner and request
referral to mental health care specialists.