The objectives of the current study, are to assess in a sample of remitted recurrently depressed patients over a 20-year follow up period: the long-term effects of PCT; the long-term predictive value of cognitive functioning on relapse and daily…
ID
Source
Brief title
Condition
- Mood disorders and disturbances NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary study parameter is: time to MDD relapse (main).
Secondary outcome
Secondary study parameters are: number and severity of MDD relapses over 20
years; current cognitive, and daily functioning; 20-year changes in cognitive
functioning; affective functioning (emotions); dysfunctional attitudes; health
care use; and course of (subclinical) depressive symptoms; cognitive effort
(neuropsychological symptom validity).
Background summary
Major depressive disorder (MDD) is highly prevalent with high relapse rates,
especially in patients with recurrent episodes. It is therefore essential to
advance knowledge on preventative methods such as Preventative Cognitive
Therapy (PCT). Gaining more insight into factors associated with relapse such
as cognitive impairment and reduced daily functioning can facilitate optimizing
preventative methods. To this date, questions remain regarding long-term
effects of PCT, the predictive value of cognitive impairment, long term changes
in cognitive functioning, and the nature of the relationship between relapse,
cognitive, and daily functioning in patients with recurrent depression.
Study objective
The objectives of the current study, are to assess in a sample of remitted
recurrently depressed patients over a 20-year follow up period: the long-term
effects of PCT; the long-term predictive value of cognitive functioning on
relapse and daily functioning; changes in cognitive functioning; and whether
MDD-related variables predict possible change.
Study design
This is a long-term follow-up of a randomized controlled trial (DELTA).
Study burden and risks
For the current follow-up study, participants wil be subjected to a clinical
interview (65-80 minutes) and neuropsychological testing (80 min.).
Participants will also be invited to fill in four questionnaires (35 min.). The
total time investment for participants is approximately 180-195 min. There are
no risks for the participants. If preferred, participants receive an oral
report of their individual assessment outcomes. If applicable, participants
will be advised how and where to seek professional help. Contributing to
knowledge about aspects of a condition participants experienced themselves, may
be rewarding.
Meibergdreef 5
Amsterdam 1105AZ
NL
Meibergdreef 5
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
All individuals (n <= 187) who participated in the DELTA study (Bockting et al.,
2005) 20 years ago, are eligible for the present follow-up study. There are no
additional inclusion criteria to be invited to participate in the present
follow-up study.
Exclusion criteria
There are no additional exclusion criteria.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL75326.018.20 |