In this project, we focus on the cortical network (connectome) involved in visuomotor control. The projects aims to:- Map out higher order visual and motor functions in primary brain tumour patients. - Explain variability in performance on the basis…
ID
Source
Brief title
Condition
- Nervous system neoplasms malignant and unspecified NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
- Performance on visuomotor tasks
- Connectivity parameters from DTI and MRI
Secondary outcome
• Tumor histology
• Performance on neuropsychological tests that tap into different cognitive
abilities such as memory, attention or emotion.
Background summary
Neurocognitive functioning has become an important outcome measure in the
treatment of brain tumours in order to uphold quality of life as much as
possible. However, cognitive outcome is diverse and difficult to explain on the
basis of tumour location alone. Complaints can be a consequence of tumour
infiltration or displacement of brain structures (mass effect) and depend on
the growth rate and character of the tumour tissue. It is increasingly
recognized that brain tumours can induce both local and widespread dysfunction
of brain networks, and symptoms are the result of both.
From literature and clinical practice there are indications of impairments in
higher-order visual and motor functions in a large proportion of patients, but
this received little attention so far. This project aims to evaluate
functioning in this domain and to explain variability in cognitive outcome pre-
and post tumour surgery using structural and functional brain connectivity
measures.
Study objective
In this project, we focus on the cortical network (connectome) involved in
visuomotor control. The projects aims to:
- Map out higher order visual and motor functions in primary brain tumour
patients.
- Explain variability in performance on the basis of structural and functional
brain connectivity pre- and post tumor surgery.
Study design
Study design: monocenter cohort study.
Methods: Participation entails visual and visuomotor test battery (1.5 hours)
added to the standard neuropsychological assessment pre- and postoperatively.
In addition, we ask permission to use clinical data from the neuropsychological
assessment , MRI scan and neurological correspondence regarding diagnosis and
medical history.
Study burden and risks
The proposed project has no known health risks. Participants may experience
discomfort during the MRI session or neuropsychological examination, which will
be carefully monitored. Participation offers no direct benefit for patients.
The information acquired by this research project will improve our
understanding of the effects of a brain tumour on (visuomotor) outcome and can
be utilized to predict outcome in the future.
Heidelberglaan 100
Utrecht 3584 CX
NL
Heidelberglaan 100
Utrecht 3584 CX
NL
Listed location countries
Age
Inclusion criteria
1) Age 18 - 80 years;
2) Dutch speaking.
3) Pre-operative radiological working diagnosis of primary brain tumour, with a
clinical indication for (awake) resective surgery; and/or demonstrable or
subjective visual impairments due to suspected brain damage (e.g. head injury,
epilepsy)
Exclusion criteria
1) Contra-indication for 3T MRI scanning;
2) Previous brain tumour treatment (i.e. resective brain surgery/ cranial
irradiation /chemotherapy);
3) History of stroke, traumatic brain injury or any other neurological
diagnosis that is known to affect cognition;
4) Co-morbid psychiatric disorder strongly interfering with cognitive
functioning (e.g. schizophrenia).
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL66023.041.18 |