To identify neuronal activation patterns in response to cognitive stimuli
ID
Source
Brief title
Condition
- Seizures (incl subtypes)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameter will be the topographic characterization of the neural
activity during the processing of different sensory stimuli and the performance
of attention as well as short-term memory tasks. The neural activity will be
measured by ECoG and by functional magnetic resonance imaging (fMRI)
Secondary outcome
N.A.
Background summary
Cognitive stimuli processing is extremely important for humans. Neuronal
activation patterns offer insight into cognitive processes. Most non-invasive
methods have disadvantages of a limited temporal (fMRI) or spatial resolution
(surface EEG). Registration with an intracranial grid electrode (ECoG) can
overcome this problem. A combination of ECoG with fMRI can increase our
understanding of cognitive processing in healthy controls and patients with
epilepsy.
Study objective
To identify neuronal activation patterns in response to cognitive stimuli
Study design
Observational study
Study burden and risks
Participation will imply a test with repetitive stimulation of one of the
sensory modalities (vision, hearing etc.). For hearing: they listen to music,
or phonemes or words passively, are will be asked to attend to certain
characteristics in the stimuli. For vision: they will read letters or words and
are asked to remember them and to recall them afterward. The test is harmless.
The grid electrode will not be left longer in situ than clinically necessary.
The fMRI at 7T (for patients and controls) carries no risks, though several
precautions are taken.
P. Debyelaan 25
Maastricht 6228WX
NL
P. Debyelaan 25
Maastricht 6228WX
NL
Listed location countries
Age
Inclusion criteria
Medically refractory epilepsy
Diagnostic workup up till that moment has not led to decline the patient for
resective epilepsy surgery
A suspected (neo-)cortical seizure focus at the surface of the brain
Planned implantation of intracranial electrodes
Incapacitating epilepsy or seizures (no absolute minimal frequency)
Minimum age 18 years
Exclusion criteria
For patients
• Patients with (co-existent) psychogenic, non-epileptic attacks, or low IQ
(below 70).
• (post-ictal) psychosis during the registration period will lead to exclusion
from the research., For both patients as well as for controls:
1. Head injury with intracranial abnormalities (cerebral contusion)
2. Stroke (hemorrhagic or ischemic)
3. Metallic prostheses or pacemaker in the subject*s body or other contra
indications for MRI. , For the healthy subjects only:
1. Any neurological or psychiatric disease
2. Use of medication affecting the central nervous system
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL47496.068.14 |