In this study, we therefore aim to investigate how trained immunity is systemically regulated in kidney transplant patients and how the degree of trained immunity affects graft survival in patients. A better understanding of these processes…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
niertransplantatie
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
1. The trained immunity profile of monocytes from renal transplant patients.
Before, one week after, and three months after renal transplantation, blood is
drawn from patients and circulating monocytes are isolated to examine the
activity, transcriptome, and epigenome of these monocytes.
2. The association between trained immunity and renal transplant survival.
The association between the trained immunity profile as measured in (1) and
graft survival in the first two years after transplantation is investigated.
Secondary outcome
1. The association between trained immunity and inflammation and tissue damage.
The association between the trained immunity profile as measured in (1) and
markers for tissue damage and systemic inflammation is investigated.
2. The association between trained immunity and the concentration of
immunosuppressive drugs in the blood of patients.
3. The association between trained immunity and the amount of white blood cells
and subsets of white blood cells.
Background summary
Kidney transplantation is an important treatment for renal failure. To enable
kidney transplantation and prevent rejection, immunosuppressive mediation is
needed. This medication is now mainly directed at cells of the adaptive immune
system (T and B cells). However, cells of the innate immune system also play an
important role in transplant immunology. In this study, we investigate trained
immunity in kidney transplant patients. Trained immunity is a form of memory of
innate immune cells, which causes higher inflammatory activity upon
stimulation. Our hypothesis is that trained immunity may lead to activation of
the immune response against the graft and have negative effects on graft
survival.
Study objective
In this study, we therefore aim to investigate how trained immunity is
systemically regulated in kidney transplant patients and how the degree of
trained immunity affects graft survival in patients. A better understanding of
these processes contributes to the discovery of new targets for therapy for
transplant patients, which could increase graft survival.
Study design
This is a clinical observational study.
Study burden and risks
It is an observational study in which participants donate blood. In our
opinion, there are no risks associated with this. The burden or participating
in this study is minimal.
Geert Grooteplein Zuid 8
Nijmegen 6525 GA
NL
Geert Grooteplein Zuid 8
Nijmegen 6525 GA
NL
Listed location countries
Age
Inclusion criteria
Kidney transplant recipient
Age 18 - 80 years
Exclusion criteria
No informed consent
Infection in the past four weeks
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL84277.091.23 |