The primary objective is to test the feasibility of daily adaptive radiotherapy plan based on the cone beam CT. The expectance is that this new technique will make the radiotherapy more precise which results in less side effects or patient could…
ID
Source
Brief title
Condition
- Miscellaneous and site unspecified neoplasms benign
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The feasibility of online CBCT-guided adaptive radiation therapy on a standard
Elekta Linac.
Secondary outcome
Treatment associated >= grade 3 acute toxicity according to the NCI Common
Terminology Criteria of Adverse Events (CTCAE version 4.03).
Background summary
The radiotherapy plan is generally based on a single Computed Tomography (CT)
scan obtained before the start of the treatment. However, the tumor and
surrounding tissues change during the treatment schedule in position, shape and
size. To make sure the tumor is treated, safety margins are accounted for. This
however results in that more healthy tissue will also receive radiotherapy
which will lead to more side effects.
On the Elektra linac a cone beam CT is connected. This cone beam CT is
currently used for positioning the radiation plan towards the patient. However,
the radiation would be precizer if the radiotherapy plan would be adjusted
based on the cone beam CT.
Study objective
The primary objective is to test the feasibility of daily adaptive radiotherapy
plan based on the cone beam CT.
The expectance is that this new technique will make the radiotherapy more
precise which results in less side effects or patient could receive a higher
radiation dose.
Study design
Prospective, non-randomized trial
Intervention
In parallel cohorts, multiple implementations of CBCT-guided online adaptive
radiotherapy are studied conform the specific study manual.
Study burden and risks
The extra scans will take more time. Furthermore, the patient is exposed to
more radiation caused by the extra scans.
Plesmanlaan 121
Amsterdam 1066CX
NL
Plesmanlaan 121
Amsterdam 1066CX
NL
Listed location countries
Age
Inclusion criteria
Patient with tumor type of one of the cohorts
Age >= 18 years
Scheduled to undergo online adaptive CBCT-guided radiation therapy.
WHO performance score 0*3.
Ability to give oral and written informed consent
Exclusion criteria
Pregnancy
Design
Recruitment
Medical products/devices used
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL83893.041.23 |