To develop a deep learned super-resolution model that predicts high-resolution images with a peak signal-to-noise ratio of 37dB or higher.
ID
Source
Brief title
Condition
- Nervous system, skull and spine therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Peak signal-to-noise ratio measured in decibels.
Secondary outcome
N/A
Background summary
Better targeting of the subthalamic nucleus (STN) improves the outcome of deep
brain stimulation (DBS) for Parkinson*s disease. Yet, the accuracy of
delineating the STN, and therefore the targeting, is limited by the spatial
resolution of the magnetic resonance (MR) imaging. The current study aims to
acquire a high resolution (HR) MR dataset, tailored to visualise the STN, to
train a super-resolution model to predict HR MR images based on lower
resolution MR input. This model will aid delineating the STN and improve
segmentation and targeting.
Study objective
To develop a deep learned super-resolution model that predicts high-resolution
images with a peak signal-to-noise ratio of 37dB or higher.
Study design
Prospective observational study.
Study burden and risks
All subjects routinely undergo a preoperative MR scan under general
anaesthesia. In this study, the extended scanning protocol results in an
additional 45 minutes of general anaesthesia. The additional risk of extending
the general anaesthesia by 30 minutes, before the actual surgical procedure
starts, is considered minimal by a dedicated neuroanaesthesiologist. No risks
are associated with the extended scanning protocol itself. This study will not
benefit participants directly.
Geert Grooteplein Zuid 10
Nijmegen 6525GA
NL
Geert Grooteplein Zuid 10
Nijmegen 6525GA
NL
Listed location countries
Age
Inclusion criteria
Being a patient eligible for bilateral subthalamic nucleus deep brain
stimulation surgery for Parkinson's disease.
Having signed informed consent.
Exclusion criteria
Any significant intracranial abnormality that is not in line with Parkinson's
disease progression.
Previous intracranial surgery.
A female that is pregnant at the time of enrollment.
Any significant medical condition that is likely to interfere with study
procedures.
Participation in any other clinical trial (e.g. drug, device, or biologics)
concurrently or within the preceding 30 days.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL81286.091.22 |