Retro-PROFIT; PReservation Of female Fertility In oncologic Treatment
Fertility, pregnancy and quality of life after fertility-sparing treatment for gynaecological cancer.

Every year, approximately 350 women between 18-39 years old are diagnosed with
cervical, ovarian or endometrial cancer in the Netherlands. This age group is
called AYAs (adolescents and young adults). Due to early detection and
advancements in cancer treatment, survival of patients has improved. As a
result, the focus of oncologic treatment has expanded from survival only,
towards quality of life (QoL) after surviving cancer. Preservation of fertility
is an important factor to achieve good QoL in AYAs. However, fertility can be
impaired by surgery or gonadotoxic effects of cancer treatment. Therefore,
fertility-sparing treatment could be offered to patients with early stage
disease and the wish to preserve fertility. However, data on oncological safety
and obstetrical outcomes after these procedures are scarce and based on small
retrospective series. Furthermore, the majority of these women eventually
decide not to pursue pregnancy after fertility-sparing treatment. The factors
that influence these decisions regarding fertility-sparing treatment and
pursuit of a subsequent pregnancy, and the psychological consequences of these
choices are unknown. With this study, we will create a large national
retrospective database on oncologic, obstetric and psychologic outcomes after
fertility-sparing treatment in gynaecological cancers. This will provide
sufficient data to help future AYAs to make a well-informed decision on their
preferred cancer treatment in the light of oncological and psychological
consequences of the chosen treatment modality.

Primary Objectives:
Determine oncologic outcomes after fertility-sparing treatment in AYAs with
cervical, ovarian or endometrial cancer (Q1).
Determine fertility and obstetric outcomes after fertility-sparing treatment in
AYAs with cervical, ovarian or endometrial cancer (Q2).
Determine factors that influence initiation of pursuing pregnancy, and
psychological outcomes in AYAs with cervical, ovarian or endometrial cancer
(Q3).

National, multicentre, retrospective and cross-sectional study. Collection of
data using electronic health records (EHRs), self-report questionnaires,
semi-structured interviews.

Participation is not associated with any risks. A psychological burden could be
experienced by filling out the questionnaires, since the questions are related
to fertility, (possible unfulfilled) pregnancy wish, concerns, and regret.
However, participation is voluntary, and patients can withdraw from
participation at any time. The duration of all (online) questionnaires is 30-45
minutes (Q2/Q3). The interview study will take maximum of 45 minutes. 48 women
and 12 partners will be invited. These interviews take place on location or via
teams. The interviews with the partner will be held seperately.
There are no direct benefits for participants in this study. However, with
their participation they contribute to the collection of important data to
improve the care of future AYAs with a wish to preserve fertility after cancer
treatment.