In this project, we hypothesize that presence of genetic variants associated with earlier age of natural menopause might be involved in diminished responsiveness of the ovaries to exogenous FSH stimulation during IVF treatment. Furthermore, we aim…
ID
Source
Brief title
Condition
- Sexual function and fertility disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The primary outcome parameter is the responsiveness of the ovaries to exogenous
FSH stimulation during IVF treatment, i.e. number of retrieved oocytes.
Secondary outcome
Secondary study parameters are other outcomes of the IVF treatment, described
by the number of follicles after stimulation, quality of retrieved oocytes,
quality of embryo*s as well as pregnancy rate and live-birth rate.
Background summary
Over the last decade genome-wide association studies (GWAS) have identified
hundreds of common genetic variants (Single Nucleotide Polymorphisms, SNPs)
associated with age of natural menopause (ANM). The peri-menopausal stage is
preceded by a decrease in fertility eventually leading to sterility in the 10
years before menopause. Poor response to controlled ovarian hyperstimulation
(COH) during IVF treatment is a reasonable predictor of diminished ovarian
reserve. Therefore, we hypothesize that presence of genetic variants associated
with earlier age of natural menopause might also be involved in diminished
responsiveness of the ovaries to exogenous FSH stimulation during IVF
treatment. In other words, patients that carry more SNPs associated with early
age of menopause might as well have a poor response to COH treatment.
Consequently, if that is the case, these SNPs might be used as a predictor for
ovarian response during IVF treatment using polygenic risk scores.
Study objective
In this project, we hypothesize that presence of genetic variants associated
with earlier age of natural menopause might be involved in diminished
responsiveness of the ovaries to exogenous FSH stimulation during IVF
treatment. Furthermore, we aim to investigate whether polygenic risk scores of
genetic variants associated with age at natural menopause based on the
large-scale GWAS are predictive of the response to IVF stimulation in patients
starting their first IVF treatment cycle leading to a more patient-tailored
care-setting.
Study design
This candidate gene study will be conducted in a retrospective as well as
prospective cohort study.
Study burden and risks
Single blood sampling is needed to execute this candidate gene study, although
this will be combined with standard blood sampling women will need to visit the
hospital one extra time.
Dr. Molewaterplein 40
Rotterdam 3015 GD
NL
Dr. Molewaterplein 40
Rotterdam 3015 GD
NL
Listed location countries
Age
Inclusion criteria
- A regular menstrual cycle
- Undergoing IVF because of male infertility or unexplained infertility
- First cycle IVF treatment
- Age between 18 and 45 years
Exclusion criteria
- A history of ovarian surgery, chemotherapy of radiation therapy
- Non Northern European ethnicity
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
In other registers
| Register | ID |
|---|---|
| CCMO | NL75062.078.20 |
| OMON | NL-OMON28369 |