What is the cost-effectiveness of a cognitive control training (CCT) as an add-on intervention in elderly depressed patients (EDP)?
ID
Source
Brief title
Condition
- Mood disorders and disturbances NEC
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Investigate whether the training could change patients* depressive symptoms
into a positive direction.
Secondary outcome
Rumination (state en trait)
Working memory
Cognitive functioning
Cognitive coping strategy
Emotional executive functioning and inhibition
Cost-effectiveness
Budget-impact analysis
Implementation study
Background summary
Major Depressive Disorder (MDD) is a severe, highly prevalent (20% lifetime
prevalence in the Netherlands) and often chronically recurrent psychiatric
illness. Approximately one in every 50 community-dwelling adults aged 65 years
or older meet the criteria for MDD in the past year (Kessler et al., 2010).
They suffer from perturbations in their affect, weight, sleep patterns, ability
to concentrate, and/or suffer from feelings of worthlessness. Unfortunately,
geriatric depressed patients seem less responsive to standard treatment
protocols and demonstrate a higher rate of chronicity than younger patients
(Netherlands Study of Depression in Old age, NESDO). The high recurrence rate
of depression suggests that current treatments are not able to modify
vulnerability mechanisms that trigger relapse. A major risk factor for
depression is impaired cognitive control (De Raedt & Koster, 2010). Therefore,
researchers started to use cognitive control training (CCT) as an add-on
intervention for depression. Results of this research line are encouraging, as
cognitive control training seems to reduce depressive symptoms by targeting a
crucial risk factor for the relapse of depression. Importantly, the training of
cognitive control has proven to be especially effective in elderly depressed
patients (EDP), specifically long-term (Brunoni et al., 2014).
In the proposed project, we aim to implement a promising cognitive control
training that is based on (1) an individual computerized assessment, and (2)
that trains specific cognitive impairments which are known to be critical for
the depressive symptomatology and the recurrence of the disorder. The training
will be administered in EDP who continue receiving treatment as usual.
Study objective
What is the cost-effectiveness of a cognitive control training (CCT) as an
add-on intervention in elderly depressed patients (EDP)?
Study design
A randomized controlled trial with two arms, in patients receiving treatment as
usual (TAU).
Study burden and risks
The burden is approximately 7 hours of filling out questionnaires and doing
computer tasks. Since it concernes a computerized add-on intervention that
patients can perform from their own homes, the expected effort is low. There
are no know risks associated with filling out the questionnaires or doing the
computer tasks.
Montessorilaan 3
Nijmegen 6500 HE
NL
Montessorilaan 3
Nijmegen 6500 HE
NL
Listed location countries
Age
Inclusion criteria
Eligible patients are 60 years or older with MDD who attend old-age psychiatry
outpatient care
of GGNet or ProPersona as secondary treatment centers, and the outpatient
clinic for the elderly of the Department of Psychiatry of the Radboudumc. All
patients receive standard treatment for the primary diagnosis of MDD according
to the multidisciplinary Dutch guideline for depression (addendum elderly).
Exclusion criteria
Psychotic symptoms or diagnoses, (hypo)mania, bipolar disorder, primary
diagnosis of substance abuse or dependence or alcohol abuse or dependence, as
well as severe neurocognitive disorders, severe visual disabilities that
interfere with the computer task, acute suicidal risk will
serve as exclusion criteria.
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL67671.091.18 |