Our primary objective is to test temporal microRNA profiles in patients presented by the emergency services to the emergency room with a suspicion of acute (i.e.
ID
Source
Brief title
Condition
- Central nervous system vascular disorders
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
In-between differences in microRNA profiles on admission to the emergency
department and within differences in each group in time.
Secondary outcome
clinical characteristics and radiological outcomes of the patients (all
gathered in routine clinical practice)
Background summary
Diagnosis of ischemic stroke should be rapid for clinical efficacy of
reperfusion therapy and reliable in order not to miss stroke patients or expose
non-stroke patients to reperfusion related complications. Currently stroke
diagnosis is time consuming with a low specificity. Recently micro-RNA*s have
showed to be very promising as a stroke biomarker but was never compared in
acute ischemic stroke patients, haemorrhagic stroke patients or stroke mimics
(i.e. stroke simulating conditions). We hypothesize that (a combination of)
specific (freely circulating) microRNA*s can be used as biomarkers to establish
diagnosis of acute ischemic stroke.
Study objective
Our primary objective is to test temporal microRNA profiles in patients
presented by the emergency services to the emergency room with a suspicion of
acute (i.e. <6 hours) ischemic stroke
Study design
observational study
Study burden and risks
Sampling of additional plasma for study purposes (2 x 10 ml per blood draw)
will be done as much as possible within regular blood sampling as is part of
routine care. We aim to sample plasma for study purposes on the following time
points (total: 4): admission, day 1 and 2-5 and after 6 to 8 weeks. In practice
routine samples will be performed on admission for all patients (t=0) and day
after admission for groups A and B (t=1). The study carries no inherent risks.
Albinusdreef, 2
Leiden 2333 ZA
NL
Albinusdreef, 2
Leiden 2333 ZA
NL
Listed location countries
Age
Inclusion criteria
1) Patients considered potentially eligible by EMS personnel for IVT/IAT for
whom a pre-
stroke alarm is initiated.
2) For patients included in the IS group: a National Institutes of Health
Stroke Scale >=4 or eligible for reperfusion treatment
3) Age >=18 years
4) For patients included in the IS or HS group: clinical admission on the
neurology ward
Exclusion criteria
- Use of therapeutic heparin within 24 hours before onset of symptoms
- Extracranial malignancy (patients can be included if they have a prior
history of malignancy if the patient received curative treatment)
- Alteplase treatment started
Design
Recruitment
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL63060.058.17 |