The main objective of this study is to investigate the acute beneficial effect of moderate inten-sive exercise (defined as walking) on neurocognitive functioning in healthy children and adults with mild CP, GMFCS I and II and if this effect is…
ID
Source
Brief title
Condition
- Congenital and peripartum neurological conditions
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main outcome measure is executive functioning. Neurocognitive functioning
(inhibition, attention/switching and processing speed) will be assessed with
three short neuropsychological tests. Used tests:
Children: 'Opposite worlds' and 'Creature counting' from the TEA-CH (Test of
Everyday Attention for Children); 'Coding&Symbol Search' from the WISC-V.
Adults: Stroop Color and Word test; 'Visual elevator' from the TEA (Test of
Everyday Attention for Adults); 'Coding&Symbol Search' from the WAIS-IV.
Secondary outcome
Secondary outcome measures are endurance and temporal spatial gait parameters
(stride length, step length, velocity, symmetry and cadence). Endurance will be
measured with the 2-minute walk test. Temporal-spatial gait parameters will be
measured with the GAITRite system and accelerometer.
Background summary
Due to early onset problems with movement and posture, children and later as
they become adults with cerebral palsy (CP) lead more sedentary lives than
their able peers. The early brain damage which causes motor problems, can also
cause cognitive deficits. Numerous studies point to a positive relation between
physical exercise and executive functions (EF). However, only a few have
studied the effect of physical exercise on cognitive functioning in people with
CP. Motor movement and endurance could be supported by listening to music
during walking. When listening to music makes walking less strenuous, it is
expected cognitive functioning will also improve.
Study objective
The main objective of this study is to investigate the acute beneficial effect
of moderate inten-sive exercise (defined as walking) on neurocognitive
functioning in healthy children and adults with mild CP, GMFCS I and II and if
this effect is larger when music is added during walking. The secondary
objective is to investigate the effect of music on gait pattern and endurance.
Study design
The study is designed as a Randomized Controlled Trail. In this design we
include three groups: two experimental groups and one control group.
Intervention
In this study, one experimental condition consists of a child-group and an
adult-group walking with music during an interval of 10 to maximal 20 minutes.
The other experimental condition consists of a child-group and an adult-group
walking without music during an interval of 10 to maximal 20 minutes. The
control condition consists of a child-group and an adult-group who remain
inactive during 20 minutes. Neurocognitive functioning will be measured once
before and twice after the described intervention with a set of three short
neuropsychological tests. A third measurement will take place after a 20
minutes brake. Gait pattern and endurance will be measured once before and
during the walking interval in the experimental conditions.
Study burden and risks
All participants in the experimental conditions undergo the walking
intervention, which is expected to be beneficial for neurocognitive functioning
for most participants. Participants who walk with music are also expected to
improve on endurance and gait pattern. The effects are expected to be transient
effects, not lasting effects. The burdening of walking does not exceed the
burdening of regular gait training most participants receive during
rehabilitation. The duration of walking can be adjusted to the capabilities of
the participants and can be less than 20 minutes. There are no extra risks
associated with participating in this study. The activities during the
intervention resemble normal activities during school time and/or daily life.
The duration of the whole intervention (including the intake) is 150 minutes.
This can be experiences as long, especially by young children. It is also
possible participants will feel tired after the intervention and may experience
some muscle pain afterwards.
Because children with CP are still developing their gait pattern and
neurocognitive functioning, it is important to include them in our study.
Results from the child-group can be used in therapy and education to optimize
their development. The results that will be obtained from the adult-group with
CP are not representative for the child-group, because the adult gait pattern
and neurocognitive functioning has already developed. For this group, results
could be used as an easy and non-invasive manner to ease walking and prevent a
decline in walking ability and neurocognitive functioning.
Van der Boechorststaat 7
Amsterdam 1081 BT
NL
Van der Boechorststaat 7
Amsterdam 1081 BT
NL
Listed location countries
Age
Inclusion criteria
Cerebral palsy
8-16 year
40 year or older
GMFCS level I-II
MACS level I-II or being able to perform the tests manually
Being able to walk independently
Exclusion criteria
Deafness
Contra-indication to perform moderate physical exercise
Uncontrolled seizure disorder
Recent lower limb surgery
Severe visual difficulties
Mentally incompetence
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL74253.029.20 |