The objective of this study is to investigate which pathways explain the association between social jetlag, insulin sensitivity and glucose metabolism in people with prediabetes with and without social jetlag.
ID
Source
Brief title
Condition
- Glucose metabolism disorders (incl diabetes mellitus)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The first main outcome is glycaemic control, measured with fasting blood
glucose levels, HbA1c levels, and 2h glucose levels after an oral glucose
tolerance test, comparing those with and without social jetlag.
Secondary outcome
Additionally, to assess which factors mediate this association, we will assess
physical activity, (para)sympathetic nervous systemactivity from ECGs and
electrochemical skin conductance tests, the Dim Light Melatonin Onset (DLMO) in
saliva samples, HPA-axisactivation from cortisol awakening reaction in saliva
samples and visceral fat distribution.Physical activity and sleep times and
phases will be measured using an activity tracker and a sleep measuring
headband. Dietaryintake will be assessed from the central Hoorn Study visit (or
the RISC of HOM study visit).
Background summary
Social jetlag is defined as the discrepancy between work schedules, social
obligations and biological needs. The effects of social jetlag on our
metabolism and health have been studied during the past years in the general
population, and social jetlag has been associated specifically with adverse
glycaemic measures, and parameters of metabolic syndrome and Type 2 Diabetes
(T2D) in the general population. The pathways that explain these associations
are still under debate.
Study objective
The objective of this study is to investigate which pathways explain the
association between social jetlag, insulin sensitivity and glucose metabolism
in people with prediabetes with and without social jetlag.
Study design
A small observational study conducted in people with prediabetes from the Hoorn
Study Cohort.
Study burden and risks
Participants will perform some of the measurements themselves from home, and
will come to the research centre twice, where they will undergo several
assessments. They will undergo non-invasive ECGs(twice), skin conductance tests
(twice), saliva collection (9 times), and will fill out 5 questionnaires. More
invasive measurementsthat will be performed are a blood draw, which will be
done two times from a cannula to perform an OGTT and measure HbA1c.
Meibergdreef 9
Amsterdam 1105 AZ
NL
Meibergdreef 9
Amsterdam 1105 AZ
NL
Listed location countries
Age
Inclusion criteria
40 participants with prediabetes (FPG 6.1-7.0mmol/l) who have provided consent
to be informed about future research will be identified in the New Hoorn Study
Cohort in the measurement of 2021-2023. 20 of them having more than 1 hour of
social jetlag and 20 of them having less than 1 hour of social jetlag.
Exclusion criteria
Excessive alcohol use (>14 alcoholic consumptions per week)
Having crossed more than 1 time zone in the month prior to participation
Working shifts more than once per month
Unable to give written informed consent
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL80321.029.22 |