This study aims to examine the interactive effect of indoor air quality and temperature on human cognitive performance. The main research objective of this study is to examine how poor indoor air quality in terms of 900 ppm CO2 compared to 3,000 ppm…
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Source
Brief title
Condition
- Other condition
Synonym
Health condition
De cognitieve prestaties van gezonde deelnemers
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The main study parameters are the achieved scores of the cognition test, mainly
derived from the CANTAB Cognition Test and the Cognitive Ability Task.
Secondary outcome
As secondary research objectives, it is additionally examined if humans
perceive the air quality as less pleasant under the higher temperature, even if
the air quality itself does not change in terms of carbon dioxide
concentration. Also, the physiological reaction towards poor air quality and
elevated temperature will be examined in isolation and interaction.
Specifically, it will be investigated how these two factors affect the
following physiological parameters: Capillary blood CO2 and pH level, salivary
cortisol and alpha-amylase, blood cytokins serum concentration, lung function,
heart rate, respiration rate, skin temperature, core temperature, blood
pressure, physical activity, and metabolic rate.
Background summary
The indoor environmental quality of buildings has a profound impact on
occupants* cognition and health. Humans living in developed economies spend
nearly 90 percent of their time indoors, either working, sleeping or following
recreational activities. The indoor environment became an important factor with
a large body of evidence emphasizing the strong impact buildings have on
workers* productivity. Western economies shift their production capital more
and more towards services, thus knowledge workers, who create value with their
brain power, become an increasingly important production factor for these
economies. Studies have shown that the indoor environment in school buildings
has a strong effect on the academic performance of university students and
pupils at school. Suboptimal indoor air quality and thermal environment hence
may impair academic achievements, which can decrease human capital
accumulation, earning potential and job market success later in life. Thus,
real estate developers, architects and health scientists examined the effect
the indoor air quality and indoor thermal environment have on human cognitive
performance. Past research reveals that a low supply of fresh outside air into
buildings lead to the accumulation of carbon dioxide and other air pollutants
emitted by the occupants and the building environment itself. Mechanical
ventilation is often not provided in buildings in Europe, especially for older
buildings. It has been shown that humans sitting in insufficiently ventilated
rooms show poorer cognitive performance than their counterparts sitting in
rooms with higher ventilation rates. Additionally, evidence from literature
shows that higher temperatures can also negatively affect human cognitive
performance. In the last decades, more frequent, longer lasting and extremer
heat waves have been recorded in Europe. Because only a small share of the
office and school building stock in Europe is equipped with air conditioning,
most occupants have to withstand uncomfortable heat indoors in office and
school buildings during such heat waves. The lack of air conditioning and
mechanical ventilation can lead to profound trade-offs that building occupants
have to make, when outdoor temperatures rise in summer and during heat waves.
On the one hand, they could keep the windows open to ensure good air quality,
but this allows hot air to enter the room and (further) heat it up. On the
other hand, if the windows are kept closed, hot air stays outside, however,
carbon dioxide and air pollutants accumulate inside. Depending on the
insulation level and building materials used, the building will heat up slower
or faster, when outside temperature and sun radiation levels stay elevated over
several days. In combination, without appropriate access to mechanical cooling
and (natural) ventilation, this leads to poor air quality and elevated
temperature indoors. Even though this trade-off is a well-known issue in the
indoor environment sector, only few studies have examined the interaction
effect of bad air quality and high temperature on humans. Most of these studies
included perceived air quality and comfort as the main outcome, showing that
higher temperature modulates the perception of air quality negatively. However,
little is known about this interactive effect with regards to cognitive
performance.
Study objective
This study aims to examine the interactive effect of indoor air quality and
temperature on human cognitive performance. The main research objective of this
study is to examine how poor indoor air quality in terms of 900 ppm CO2
compared to 3,000 ppm and elevated temperature of 35°C compared to 23°C affect
cognitive performance, respectively. Furthermore, it will be examined if a
higher temperature of 35°C compared to 23°C amplifies the negative effect of
poor air quality in terms of 3000 ppm CO2 concentration vs. 900 ppm CO2
concentration on cognitive performance?
Study design
A cross-over single-blinded treatment design will be used. Subjects will
undergo four difference conditions ((1) 900 ppm CO2 and 23°C, (2) 900 ppm CO2
and 35°C, (3) 3,000 ppm CO2 and 23°C, and (4) 3,000 ppm CO2 and 35°C). Subject
will be blinded to the air quality level; however, it is not possible to blind
them to the temperature condition due to its easy detection.
Intervention
Each subject undergoes four conditions in randomized order. Two conditions
consist of poor air quality defined as 3000 ppm carbon dioxide and 23°C or 35°C
temperature, respectively. These two temperature conditions will be repeated,
but then with good air quality defined as 900 ppm CO2.
Study burden and risks
Subjects have to come once for a screening session and then for the four
testing conditions to the MRUM lab facilities. They will stay in the
respiration room for eight hours on each test day. They have to conduct
cognition tests two times a day and fill out questionnaires about their
perception of the indoor environmental quality.
Universiteitssingel 40
Maastricht 6229 ER
NL
Universiteitssingel 40
Maastricht 6229 ER
NL
Listed location countries
Age
Inclusion criteria
Adults between 18 to 40 years old
Western-European background
Generally healthy
No medication which may influence the outcome parameters. This will be
determined
on a case-by-case basis. Contraceptive uses for women are allowed and will be
verified
through a questionnaire.
Non-smokers or persons who quit smoking more than five years ago
Exclusion criteria
• Participants, who do not want to be informed about unexpected medical
findings, or do
not wish that their treating physician will be informed, cannot participate in
this study
• Individuals with a diagnosed physical or mental disability or ADHD or
depression
• Any medication or medical condition that might interfere with the
physiological outcome
parameters or in some regards impair cognition
• Unstable body weight (weight gain or loss >3kg in the past three months)
• Participation in another biomedical study within 1 month prior to screening
visit
• Shift workers
• Colour blindness
• Pregnancy
• People with a low haemoglobin or haematocrit concentration
• Not having visited or resided in a warm country in the last 3 months
• Participants with asthma or restricted lung function due to allergies
Design
Recruitment
Medical products/devices used
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In other registers
Register | ID |
---|---|
CCMO | NL85595.068.23 |