Primary objective: To assess the effect of passive heat acclimation, in combination with low-to-moderate intensity exercise, on cardiovascular and thermophysiological responses in overweight, older individuals.Secondary objective: To assess the…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
thermoregulation
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Primary study parameters include thermophysiological parameters (core
temperature, skin temperature, and local sweat rate) and cardiovascular markers
(heart rate, blood pressure, blood flow).
Secondary outcome
Secondary study parameters include metabolic parameters (substrate oxidation,
energy expenditure, plasma glucose, insulin, total cholesterol, and free fatty
acid concentrations), brain blood flow, endothelial function, and thermal
perception (thermal sensation and comfort), and gastrointestinal tolerance.
Background summary
As the ongoing progression of climate change exposes individuals to elevated
temperatures and an escalating frequency of extreme heat events, the risk of
more intense and prolonged heat waves raises significant concerns for public
health, particularly among vulnerable populations. The physiological response
to acute heat stress involves involuntary thermolytic reactions that may strain
the cardiovascular system, especially in individuals with pre-existing
vulnerabilities. Heat acclimation has been identified as a potential strategy
to enhance thermoregulation and mitigate the adverse effects of heat stress.
While existing research primarily focuses on athletes and military, this study
aims to investigate the impact of a practical heat acclimation strategy,
combining passive and active heat exposure, on thermophysiological,
cardiovascular and metabolic parameters in healthy overweight adults. The study
targets a population at increased risk for heat-related complications, seeking
to provide realistic guidelines for broader application when a heat wave
appears on the weather forecast.
Study objective
Primary objective: To assess the effect of passive heat acclimation, in
combination with low-to-moderate intensity exercise, on cardiovascular and
thermophysiological responses in overweight, older individuals.
Secondary objective: To assess the effect of passive heat acclimation, in
combination with low-to-moderate exercise on metabolic health in overweight,
older individuals.
Study design
A non-randomized, within-subject experimental trial.
Intervention
Passive heat exposure (29-35ºC; 6h/day for 7 days) in combination with
30min/day low-to-moderate intensity cycling.
Study burden and risks
The burden and risks involved in participating in this experiment are minimal.
Insertion of the catheters in a vein is comparable to a routine blood draw,
with the only risk being a small local hematoma. The experimental trial
involves a total of 33 blood samples (390 mL) in the entire study duration. The
collected blood volume is less than the standard quantity for a blood donation
and will be fully replenished in approximately one month. Heat exposure might
cause minor discomfort for some individuals. The necessary frequent consecutive
visits may pose a challenge for some participants, requiring a commitment of
time. The participation contributes to scientific knowledge, but no direct
benefit for the participants is expected. Participants will receive a
compensation for their time investment.
Universiteitssingel 40
Maastricht 6229 ER
NL
Universiteitssingel 40
Maastricht 6229 ER
NL
Listed location countries
Age
Inclusion criteria
Healthy males and females
60 to 80 years
BMI 25-30 kg/m2
Sedentary (<2h exercise/week)
Exclusion criteria
• Presence of uncontrolled chronic cardiovascular disease, as determined by
medical history and physical examination
• Participating in a structured exercise program
• Taking hot baths/saunas regularly
• Travelled for a prolonged time to destinations with elevated temperatures the
last 3 months
• Pre-existing T2DM
• Blood donation within a month of study initiation
• People with low hemoglobin concentration (males: Hb = 13.5-17.5 g/dL,
females: Hb = 11.5-15.5 g/dL)
• Recent participation in biomedical study (less than 1 month)
• Using any medication that may influence glucose or lipid metabolism
(beta-blockers, thyroid medications, stimulants, antidepressants,
anticoagulants)
• Smoking or abuse of alcohol
• People with lactose intolerance
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL86367.068.24 |