To measure a change in Hemoglobin levels upon a change in posture from supine to upright in in ICU patients.
ID
Source
Brief title
Condition
- Anaemias nonhaemolytic and marrow depression
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
The difference in hemoglobin level between upright and supine position in the
same patient.
Secondary outcome
Other study parameters are albumin and uric acid before and after mobilisation
in chair.
Background summary
Monitoring hemoglobin levels is vital for identifying anemia causes in
hospitalized patients. Changes in posture, as demonstrated by previous research
can lead to significant shifts in hemoglobin concentrations, termed postural
pseudoanemia. However, this phenomenon has not been studied in ICU patients.
Many factors may affect hemoglobin concentrations in ICU patients, including
plasma volume shifts, bleeding, blood loss from repeated phlebotomies,
hemolysis, bone marrow suppression and functional iron deficiency. When this
leads to significant anemia patients may be treated with red blood cell
transfusions. However, these transfusions may be associated with adverse
reactions and should only be performed for appropriate indications. If postural
pseudoanemia occurs in ICU patients this could lead to patient harm through
inadvertent red blood cell transfusions. The occurrence of postural
pseudoanemia in ICU patients may differ from previous studies because patients
are frequently immobilized for prolonged periods. This study aims to
investigate whether postural changes affect hemoglobin in ICU-admitted
patients. We hypothesize that significant hemoglobin shifts may occur,
potentially leading to misinterpretations of anemia and unnecessary diagnostic
workup. Understanding this impact can guide clinical practice and prevent
unwarranted interventions.
Study objective
To measure a change in Hemoglobin levels upon a change in posture from supine
to upright in in ICU patients.
Study design
Intervention study
Study burden and risks
The first blood sample, in supine position, at 06:00 is a routine sample, taken
bij every patient admitted to the ICU.
Mobilisation in a chair is also routine, for every patient who can be mobilized.
The burden for patients participating in this study is the sampling of 2 times
8 ml of blood from the arterial line.
Nico Bolkesteinlaan 75
Deventer 7416 SE
NL
Nico Bolkesteinlaan 75
Deventer 7416 SE
NL
Listed location countries
Age
Inclusion criteria
In order to be eligible to participate in this study, a subject must meet all
of the following criteria:
• Age over 18 years, of any gender and ethnic background
• Admitted to the intensive care unit
• Able to give informed consent
• Patients with an arterial line as part of their treatment plan.
• Patients able to remain seated in chair for at least 30 minutes
• Patients able to remain supine overnight for at least 6 hours
Exclusion criteria
A potential subject who meets any of the following criteria will be excluded
from participation in this study:
• Delirium or inability to give informed consent
• Inability to understand written information in Dutch
• Patients on artificial ventilation
• Orotracheally intubated patients (spontaneous breathing through a
tracheostomy cannula is allowed)
• Patients treated with noradrenaline > 0.05 ug/kg/min
• Patients treated with argipressin
• Patients who received a blood transfusion within 24 hours before measurements
• Patients who received > 3 L of intravenous fluids within 24 hours before
measurements
• Patients who received > 500 ml of iv fluids within 4 hours of measurements
• Severe restlessness or inability to remain supine for 6 hours before initial
blood sampling
• Patients being treated with diuretics
• Patients admitted with:
• Decompensated right heart failure
• Pulmonary hypertension
• Pulmonary embolism
• Active bleeding or risk of >100 ml blood loss
• Hematological disorder/malignancy
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| Other | ClinicalTrials.org, nummer nog niet bekend |
| CCMO | NL86966.100.24 |