To examine the course of velopharyngeal insufficiency after maxillomandibular advancement in patients with obstructive sleep apnea.
ID
Source
Brief title
Condition
- Respiratory tract therapeutic procedures
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Objective outcomes:
- Nasality
Secondary outcome
Objective outcomes:
- Swallowing
- Speech
Subjective outcomes:
- Nasality
- Swallowing
- Speecht
- Regurgitation
- Quality of life
- neurosensory disturbance
Background summary
Maxillomandibular advancement (MMA) is a successful surgical treatment for
patients with moderate to severe obstructive sleep apnea (OSA). It is a form of
orthognathic surgery and it includes forward repositioning of the maxilla and
mandible to put more tension on the soft tissue and widening the upper airway.
This results in improvement of polysomnography outcomes, sleep and quality of
life. After the surgery change in velopharyngeal symptoms, such as nasality,
swallowing and speech, could exist. Some patients found improvement
velopharyngeal insufficiency (VPI), however other patients develop VPI. (Li).
There are some studies that describe VPI after orthognathic surgery in cleft
palate patients. However little is known about VPI after MMA in patients with
OSA. Using objective and subjective measurement methods, we can examine the
course of VPI after an MMA. With this understanding, we can better prepare
patients for the postoperative symptoms of an MMA. In addition, patients could
be better managed with speech therapy postoperatively.
Study objective
To examine the course of velopharyngeal insufficiency after maxillomandibular
advancement in patients with obstructive sleep apnea.
Study design
Prospective cohort study
Study burden and risks
All test are non invasive. There will be no physical and physiological
discomfort. The extra burden and risk associated with this study are
negligible.
Meibergdreef 9
Amsterdam 1105AZ
NL
Meibergdreef 9
Amsterdam 1105AZ
NL
Listed location countries
Age
Inclusion criteria
Patients with obstructive sleep apnea who undergo maxillomandibular advancement
osteotomy as treatment
Exclusion criteria
- Patients who underwent other adjunctive procedures at the time of MMA (e.g.,
multipiece Le Fort osteotomy, TMJ reconstrunction)
- Previous history of orthognathic surgery
- Previous history of oropharyngeal surgery (UPPP or multilevel surgery)
- Cleft palate and syndromic patients
- Neuromusculair diseases which causes VPI, dysphagia or dysartria
-incapacity
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL83076.018.23 |