Identification of type 2 diabetes susceptibility genes in the Duch population.
ID
Source
Brief title
Condition
- Glucose metabolism disorders (incl diabetes mellitus)
Synonym
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Construction of a DNA databank with samples from type 2 diabetes patients for
future genetic research regarding this disease.
Primary endpoint will be the association of gene variants with type 2 diabetes.
Secondary outcome
Not applicable.
Background summary
Several genetic factors influencing development of type 2 diabetes mellitus
have been identified during the past years. However, progress has been slow.
Furthermore the effect size of the known genetic susceptibility factors has
shown to be relatively low. This suggests that only a combination of several
genetic risk factors in association with a detrimental life style will
eventually lead to chronic hyperglycaemia, which is the general hallmark of
type 2 diabetes mellitus. The low impact of individual genetic defects
implicates that only sufficiently powered studies (i.e. with large sample
sizes) will be able to detect associations between a gene and the disease.
Increased knowledge about the pathogenesis of the disease and disease-related
complications might provide better prevention and treatment options for those
at risk. Moreover, it might enable us to halt the rapidly growing number of
patients worldwide.
Study objective
Identification of type 2 diabetes susceptibility genes in the Duch population.
Study design
A genetic association study using a case-control design.
The current cohort will be used in conjunction with other available cohorts of
subjects with or without type 2 diabetes (n=4000+).
Study burden and risks
Not applicable.
Postbus 9600
2300 RC Leiden
NL
Postbus 9600
2300 RC Leiden
NL
Listed location countries
Age
Inclusion criteria
Type 2 diabetes, receiving patientcare at the LUMC in 1994.
Caucasian ethnicity.
Exclusion criteria
Type 1 diabetes.
Non Cauacasian.
Design
Recruitment
metc-ldd@lumc.nl
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL18818.058.07 |