We have preliminary data from blood collected in other studies that indeed measuring blood microbiomes is more informative as sampling the corresponding faeces samples and we have built a bio-informatical pipeline that apparently allows its analysis…
ID
Source
Brief title
Condition
- Other condition
Synonym
Health condition
microbiome
Research involving
Sponsors and support
Intervention
Outcome measures
Primary outcome
Lactococcus DNA counts before, during and end of the milk-consumption
intervention.
Secondary outcome
Other microbiome DNA counts (bacteria, viruses and Archaea) in gut and blood
before and after milk consumption.
Background summary
The blood microbiome is a term used for harnessing the information present in
circulating cell-free DNA with respect to organisms present in and on the body.
Well known in this respect is that the gut microbiome, while of great
importance in maintaining host homeostasis and metabolism, can be strongly
affected spurious dietary alterations, provoking almost dramatical temporal
intra- and inter-individual variations. Nevertheless, fecal probing of the
microbiome remains the norm. The blood microbiome might be more stable,
integrating microbial information of a longer time.
Study objective
We have preliminary data from blood collected in other studies that indeed
measuring blood microbiomes is more informative as sampling the corresponding
faeces samples and we have built a bio-informatical pipeline that apparently
allows its analysis. The current study is meant to provide proof-of-concept in
this respect.
Study design
Single arm intervention study
Intervention
The participants will abstain from consumption of any dairy product for ten
days, and subsequently drink milk for consecutive 7 days (700 millimetre per
day), while concomitant consumption of other dairy products is also allowed.
Study burden and risks
Milk consumption is generally regarded as safe.
Doctor Molewaterplein 40 40
Rotterdam 3015 GD
NL
Doctor Molewaterplein 40 40
Rotterdam 3015 GD
NL
Listed location countries
Age
Inclusion criteria
- Age 18-65 years
- 18.5 =< BMI < 25 kg/m2
- All genders are included.
- Not be lactose intolerant
- Willing to consume milk
Exclusion criteria
- Regular use medications such as antibiotics, steroids, beta blockers, and
adrenergic-stimulating agents (self-report)
- Regular use prebiotic and/or probiotics apart from yoghurt and young soft
cheese (self-report)
- Antibiotic intake in the previous months (self-report)
- Daily consumption of more than 10 cigarettes (self-report)
- Chronic diseases including type 2 diabetes, hypertension, fatty liver
disease, cancer, or autoimmune disease (self-report)
- Internal diseases, including those of the gastrointestinal tract, lung,
heart, vasculature, liver, and kidney (self-report)
- Eating disorder or unconventional eating habits (self-report)
- Participation in another study (self-report)
- Women: pregnancy and breastfeeding (self-report)
Design
Recruitment
Followed up by the following (possibly more current) registration
No registrations found.
Other (possibly less up-to-date) registrations in this register
No registrations found.
In other registers
| Register | ID |
|---|---|
| CCMO | NL88008.078.24 |