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(Cost) Effectiveness of Surgery versus Prolonged Conservative Treatment in Patients with Intermittent Neurogenic Claudication caused by Lumbar Stenosis

Intermittent neurogenic claudication due to lumbar stenosis is frequently diagnosed among older persons. Due to an aging population it is to be expected the incidence of lumbar stenosis will increase over time. Patients are operated on because of…

Posture or Patching (PoP). Accelerated clearing of the media with massive vitreous hemorrhage and suspected retinal tear.

Objective: To investigate whether binocular patching in combination with posture adherence is superior to posture adherence alone in achieving visualization of the superior fundus quadrants or not.

TELEHYPE TELEmonitoring and self-management of uncontrolled HYPErtension

To assess the one-year (cost)effectiveness of telemonitoring of blood pressure and self-management support via an internet-based service in addition to usual care as compared to usual care alone in a pragmatic trial in patients with uncontrolled…

Efficacy of EMDR Resource Development and Installation in the stabilization phase of treatment of complex posttraumatic stress disorder

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Reducing symptoms of depression and anxiety in adolescents with inflammatory bowel disease in order to improve quality of life and the clinical course of disease

The primary objective is to determine the efficacy of a disease specific cognitive behavioral therapy program in adolescents with IBD and increased symptoms of depression or anxiety on reducing symptoms of depression. Secondary objectives are to…

A prospective Randomized Controlled Trial to Evaluate the Primary Prevention of sudden cardiac death using implantable cardioverter defibrillators in dialysis patients.

The main objective of this study is to assess whether ICD therapy in dialysis patients reduces sudden (arrhythmogenic) cardiac death. The first secondary end point is to compare total mortality death between the two groups. An other is to evaluate…

Intensive home visiting program for multiproblem families: Effectiveness, mediators and moderators of effects

The current project aims first to examine whether IPT produces outcomes that are superior to the comprehensive treatments already available ('care as usual'). Primary outcomes include parenting behavior and the quality of the parent-child…

HARP II-trial: Right-sided hand-assisted retroperitoneoscopic live donor nephrectomy versus standard laparoscopic living donor nephrectomy.

To determine the best approach for right-sided live donor nephrectomy i.e. to optimise donor*s safety and comfort .

Prospective, Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial Comparing REMICADE® (infliximab) and Placebo in the Prevention of Recurrence in Crohn*s Disease Patients Undergoing Surgical Resection Who Are at an Increased Risk of Recurrence

Primary ObjectiveThe primary objective of this study will be to compare the efficacy of infliximab with that of placebo in the prevention of clinical recurrence of CD through Week 76, defined as a composite endpoint that requires endoscopic…

Double-blind, placebo-controlled, multiple ascending-dose study to investigate the safety and tolerability of AZ01 in healthy volunteers.

Primary:- assess safety and tolerability and determine the maximum tolerated dose (MTD) of repeated doses or a single dose of AZ01 given as a subcutaneous (SC) or intravenous (IV) dose in healthy subjects. Dosing will not exceed the maximum feasible…

A pilot randomized controlled trial comparing the effect of a percutaneous and lipofilling technique in patients with a secondary Dupuytren*s contracture with standard fasciectomy surgery on convalenscence, contracture correction and recurrence rate.

To compare treatment of secondary Dupuytren*s contracture by standard limited (dermo)fasciectomy and by the modified percutaneous release combined with fat grafting. We focus specifically on return to function and if applicable to return to work (…

Sking hardening in polymorphic light eruption. Comparison of therapeutic effect of UVB hardening in the hospital with treatment at home with Sunshower

In this study we will evaluate the effect of Sunshower Medical device at home and compare it with the effect of customary UV hardening performed in the hospital to assess whether the former is not inferior to the latter treatment. The ultimate goal…

A randomized, open-label, comparative, multicenter trial to compare the effects on metabolic parameters of two NOMAC-E2 batches (pivotal phase III and commercial batch) and a monophasic COC containing 150 µg LNG and 30 µg EE (Phase III, Protocol No. P06447)

To compare the effects on the APC- (Activated Protein C) resistance ratio (ETP-[endogenous throbin potential] based) between the pivotal phase III NOMAC-E2 batch and a commercial NOMAC-E2 batchTo compare the effects on all other metabolic parameters…

Cost-effectiveness of treatment strategies for intermittent claudication

To evaluate the cost-effectiveness, from the perspectives of the health care system and of society at large, of supervised exercise compared to endovascular revascularization plus supervised exercise as first-line treatment of IC.

The efficacy of radioguided occult lesion localisation (ROLL) versus wire guided lesion localisation (WGL) in breast conserving surgery for non palpable breast cancer: a randomised controlled trial

To evaluate the efficacy of ROLL versus WGL in breast conserving surgery for non-palpable breast cancer.

Bard® PolySoft* pre peritoneal mesh versus Parietene* ProGrip* self-fixing semi-resorbable mesh and chronic inguinal pain development.

Objective of the Trial:Does the use of a Bard® Polysoft* preperitoneal mesh result in less chronic pain than after the use of a ProGrip*self-fixing semi-resorbable mesh for patients with an inguinal hernia repair through an anterior approach?

Towards a shortened sick leave duration of employees sick-listed due to common mental disorders

The objective of this study is to investigate:•Why do Dutch occupational physicians currently adhere only minimally to the guideline, and how can these barriers overcome? (phase 1)•Does adherence to this guideline lead to a shortened sick leave…

A Clinical Safety and Efficacy Comparison of NEVANAC® 0.1% to Vehicle
Following Cataract Surgery in Diabetic Retinopathy Patients

Demonstrate superiority of NEVANAC® (nepafenac ophthalmic suspension) 0.1% relative to nepafenac vehicle based on the percentage of diabetic retinopathy patients who develop macular edema (defined as >=30% increase from pre-operative baseline…

Viscosity of PMMA Bone Cement in Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures: A Randomized Controlled Trial

Establishment whether usage of high viscosity PMMA bone cement in PVP for OVCFs leads to a reduction in leakage incidence compared to usage of conventional (low-medium) viscosity PMMA bone cement in PVP for OVCFs.Since evidence is scarce or…

Assessment of Capnography in Monitoring Patients during Deep Sedation with Propofol

At the Centre for Contraception, Sexuality and Abortion Leiden, abortion procedures are performed under deep sedation using Propofol. Patient*s monitoring is performed by nurses qualified in patient sedation management, using pulse oximetry and…