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Use of mechanical left ventricular unloading in acute decompensated systolic heart failure complicated by cardiogenic shock

To assess the efficacy of early mechanical left ventricular unloading and standard of care (inotropes/vasopressors) versus inotropes/vasopressors alone (standard-of-care) in patients with ADHF and signs of cardiogenic shock.

A 24-week with possible extension, prospective, multicenter, randomized, double blind, placebo-controlled, 2-parallel group with a randomization 1:1, phase III study to compare efficacy and safety of oral masitinib to placebo in treatment of patients with Smouldering or Indolent Severe Systemic mastocytosis with handicap, unresponsive to optimal symptomatic treatment

To evaluate the efficacy and safety of oral masitinib versus placebo in the treatment of patients suffering from Smouldering or Indolent SevereSystemic mastocytosis with handicap unresponsive to optimal symptomatic treatment.

To determine the effectiveness of the RISE intervention on preventing major adverse cardiovascular effects (MACE), after discharge from acute hospital care in community dwelling people after first-ever stroke, who have a sedentary movement behavioural pattern. In addition, the effects on 24h activity pattern, cost-effectiveness, and usability of the RISE intervention will be investigated.

The aim of the present study is to determine the effectiveness of the RISE intervention on preventing major adverse cardiovascular effects (MACE), after discharge from acute hospital care in community dwelling people after first-ever stroke, who…

An Open-label Randomized Phase 3 Study of Tucatinib in Combination with Trastuzumab and mFOLFOX6 versus mFOLFOX6 given with or without either Cetuximab or Bevacizumabas First-line Treatment for Subjects with HER2+Metastatic Colorectal Cancer

To evaluate the efficacy and safety of tucatinib in combination with trastuzumab and mFOLFOX6 in comparison to mFOLFOX6 given with or without either bevacizumab or cetuximab as first-line (1L) treatment in adults with HER2 positive (HER2+)…

Accelerated Pacing for Improved Quality of Life in Symptomatic Atrial Fibrillation Patients undergoing Pace-and-Abate Strategy with Left Bundle Branch Area Pacing: a Randomized Controlled Pilot Trial: PACE-AF

To determine the effect of accelerated pacing (lower programmed rate of 80 bpm) compared to pacing at the standard programmed rate of 60 bpm on HRQoL in symptomatic AF patients undergo-ing pace-and-ablate strategy with LBBAP.Secondary objectives: -…

The haemostatic effect of thawed deep-frozen platelets resuspended in thawed plasma versus room temperature stored platelets in platelet additive solution in the treatment of surgical bleeding; a randomized controlled non-inferiority trial

the primary aim is to determine the effect of thawed deep-frozen platelets re-suspended in thawed deep-frozen plasma versus room temperature stored platelets in platelet additive solution for transfusion on the percentage of patients with surgical…

A comparison of pericapsular nerve group block, fascia-iliaca compartment block and femoral nerve block for pain management in patients with hip fracture in the emergency department - A randomized controlled trial

The aim of this study is to compare the efficacy and safety of preoperatively placed Pericapsular Nerve Group block (PENG), Fascia-Iliaca Compartment Block (FICB) and Femoral Nerve Block (FNB) for patients with hip fractures in the ED.

Personalizing stimulation parameters in deep brain stimulation for Parkinson*s Disease based on disease phenotype and brain connectivity: a feasibility study

In this pilot study, we aim to assess practical feasibility, technical feasibility and safety of a computational approach for programming newly implanted STN-DBS patients with PD. This computational approach will be based on patient-specific sweet…

Balloon pulmonary angioplasty versus pulmonary endarterectomy in patients with chronic thromboembolic pulmonary hypertension: a non-inferiority randomized trial

To evaluate if balloon pulmonary angioplasty (BPA) is non-inferior to pulmonary endarterectomy (PEA) in patients with chronic thromboembolic pulmonary hypertension (CTEPH) who are eligible for both treatments.

Accelerated Flap Coverage Versus Standard Timing in the Treatment of Severe Lower Extremity Musculoskeletal Injuries (*FLAP ATTACK*). Pilot trial.

1) Patient reported function, satisfaction and quality of life 2) Medical costs and productivity loss. 3) Injury-related amputation of the lower extremity; 3) Unplanned reoperations to manage infection, flap compromise, or flap loss; 4) Days in the…

ShOrt neCK AAA RAndomized Trial - ESAR and FEVAR: SOCRATES
Physician-Initiated Trial Investigating ESAR (EVAR Plus Heli-FX EndoAnchors) and FEVAR for the Treatment of Aortic Aneurysms With Short Infrarenal Aortic Neck

The aim of this randomized study is to compare the safety and performance of EndoVascular Aneurysm Repair with ESAR using Endurant + Heli-FX EndoAnchor and FEVAR using customizable grafts from Cook (Zenith Fenestrated Graft) and Terumo (Fenestrated…