213 results
Obesity is a growing world wide problem. In The Netherlands, about 10% of all men and women have a BMI of 30 kg/m2 or more. Obesity is a chronic, uncurable metabolic disorder, which is characterised by excessive fatstorage at unfavorable places.…
The aim of this study is to identify barriers and facilitators for successful implementation of the care pathway, to ultimately inform national scale-up of the pathway.
The hypothesis is that low dose GC therapy exerts its anti-inflammatory effect by virtue of a first-pass effect through the liver. It is difficult to directly address the hypothesis, but there is an indirect way of doing so: if indeed low dose GCs…
Spinal anesthesia induces several alterations in normal brain processes. Firstly, loss of afferent information increases pain sensitivity. In our previous study on the effects of spinal anesthesia (P11.221) we showed that subjects felt more pain…
Addition of Partner for Change Outcome Management System (PCOMS) to individual treatment will result in a significant decrease of drop-out compared to individual treatment without PCOMS in a forensic outpatient clinic in the Netherlands. A sub-…
1. Active sniffing decreases appetite; 2. Food choice is mainly influenced by the food odour that was perceived first.
We hypothesize that consumption of mixtures of 400 grams vegetables and/or fruits for 2 weeks will result in lower ex-vivo induced oxidative DNA damage, increased antioxidant capacity of blood plasma, reduced levels of reactive oxygen species in…
We hypoothesize that the effect that a single dose of montelukast has on exercise induced bronchoconstriction correlates with the effect it has after 8 weeks of treatment.
The optimal management of locoregionally advanced NSCLC is evolving. Multimodality treatment is rapidly becoming the most common approach to stage III NSCLC. ASCO guidelines recommend initial chemotherapy (platinum-based, 2 or 3 cycles) combined…
Recent pre-clinical experiments demonstrated that sorafenib in Oatp1b2(-/-) mice had 8-fold increased sorafenib-glucuronide blood concentrations.OATP1B1 and 1B3 are highly expressed in the human liver and facilitate the hepatocellular uptake of…
We hypothesize that CTC detection through diagnostic leukapheresis improves the detection rate among ER+, N+ primary breast cancer who have received 5 years of adjuvant endocrine therapy and will be a promising technique for risk classification in…
Objective: The primary objective of the study is determining the contributing factors in bracing for AIS. The contributing factors are determined as factors of influence in the corrective possibilities and therefore end term…
Improvement in forearm rotation.
Hyperplastic polyposis syndrome (HPS) is characterized by the presence of multiple colorectal serrated polyps and co-existent conventional adenomas and is associated with an increased colorectal cancer (CRC) risk 1-9. Considering the presumed…
Clinical guidelines are based on results of clinical trials and this is not easily generalizable to daily practice due to patient selection. Real-world observations may help to formulate recommendations in guidelines, and yield research questions…
To determine the influence of oral medicinal cannabis on the pharmacokinetics of irinotecan and docetaxel and their respective metabolites in cancer patients.
We hypothesize that TIPS placement has an significant effect on drug metabolism and bile acid metabolism.
PENG block with phenol provides better pain relieve and mobility, and therefore quality of life, compared to current pain relieve strategies in patients with a hipfracture who are not eligible for surgery
We have developed a cueing application (app) for the Google Glass platform that can guide gait in PD-patients. Our initial observations showed that external cueing with the Google Glass application decreased the number and duration of FOG episodes…