29 results
(1) To assess the effect of ARA 290 on the ventilatory response to hypoxia (and compare the effects to Epo); (2) To assess the effect of ARA 290 on the gradient over the tricuspid valve during hypoxia (and compare the effects to Epo); (3) To assess…
To gain insight into individual differences in sensitivity of the circadian system. In vivo measured by the sensitivity of melatonin suppression, thermoregulatory processes and psychological functioning to full spectrum and blue reduced light, and…
Two key questions remain to be answered to further elucidate the mechanism of action: 1) is the effect on glucose metabolism dose dependent in Type 2 diabetes patients? and 2) Does UAG decrease glucose concentrations during an oral glucose loadThis…
Primary: Assessment of the short-term effect of a Heat and Moisture Exchanger on tracheal mucociliary clearance in laryngectomized individuals. Secondary: The relationship between clinical assessment, ciliary activity and mucociliary clearance.
The central hypothesis of this project is that atorvastatin (added on standard antihypertensive treatment ARB) causes a substantial decrease in MSNA in hypertensive patients with CKD.
To investigate the effects of beclomethasone plus formoterol (in a single inhaler) versus single agents formoterol and beclomethasone dipropionate pMDI with HFA-134a propellant and placebo on the airway responses to allergen challenge. The primary…
to assess the tolerability and safety after single oral ascending doses of SAR501788 in healthy young male subjects (Part 1)to assess the tolerability and safety after repeated oral ascending doses of SAR501788 in healthy young male subjects (Part 3…
Primary objective• To assess the effect of cytochrome P450 3A4 enzyme (CYP3A4) induction by rifampicin on the pharmacokinetics (PK) of eribulin following intravenous (IV) administrationSecondary objectives• To assess the safety of eribulin when co-…
The primary aim of this study is to compare the removal of (especially protein-bound) uremic toxins between 4-hour and 8-hour HD and HDF in order to evaluate the influence of dialysis duration and of convection on the removal of uremic toxins.A…
Evaluation of the effect of treatment with the Meniett in patients with unstable Menière*s disease.
The aim of this study is to develop a valid and reliable instrument to estimate the extent to which gagging problems will interfere with adequate dental treatment and to evaluate possible progress after psychological treatment of gagging problems.
The aim of our study is to find out if and if so to what extent the acute blood pressure lowering response to ACE-inhibition depends on the variation in the ACE-phenotype. If the blood pressure response depends on ACE acitivity, measurement of ACE-…
Identify the effect of tDCS parameters on motor learning in healthy individuals by measuring effects on visuomotor adaptation rate and retention, and study the influence of a common BDNF mutation.
to evaluate the effects of GH versus withdrawal of GH, after final height is reached, on weight, body composition, psychosocial functioning, carbohydrate metabolism, circulating lipids, and respiratory function during transition period until the age…
Aim of this study is to determine the effect of isoflurane versus sevoflurane on blood pressure and systemic vascular resistance.
To determine the waste reduction, net cost savings and environmental impact attained by redispensing oral anticancer drugs that go unused by patients compared with the standard practice of disposal.
Primary Objective: The primary objective is to show that L-theanine has beneficial anxiolytic in healthy individuals. With the current experiment setup that entails the following effects of L-theanine compared to placebo:• Reduced startle effect on…
In this study, we will test whether STN-DBS related apathy can be reversed by switching stimulation to a more dorsal contact on the electrode.
The aim of this study is to investigate 1. the extent to which patients who have paresis/non-spastic paralysis of the lower extremity and who are moderately active experience an improvement in the (trunk) balance through the use of a computer-…
Primary objective: To accurately assess the direct functional consequences of high versus low phenylalanine levels in adult patients with PKU, using eye-hand coordination testing in tasks of different cognitive complexity. Secondary objective: To…