Search for a trial

A study on a variant of the Continuous Performance Test: RANDI

The main aim of this study is to collect normative data on the RANDI for several age groups.

A 2-part randomized, three-period cross-over, placebo controlled, proof of mechanism study to investigate the effect of RO5285119 on vasopressin (AVP) pathway activation in healthy male subjects

Primary Objectives- To replicate AVP-induced inhibition of anterior cingulate cortex (ACC) activity and functional connectivity as measured by BOLD fMRI during a face matching task. - To assess the effect of RO5285119 in the modulation of AVP…

Effectiveness of methylphenidate in children and adults with Smith Magenis syndrome and attention-deficit/hyperactivity disorder: An N-of-1 series

The primary objective is to determine the efficacy of methylphenidate on ADHD symptoms in Smith Magenis syndrome.The secondary objectives include the efficacy of methylphenidate on emotion dysregulation and specific goals that are important to the…

An adaptive, randomized, double-blind, placebo-controlled, single and multiple ascending dose study to examine the safety, tolerability, pharmacokinetics, pharmacodynamics and food effect of RGH-338 in healthy male volunteers.

To investigate the safety and tolerability, and to characterise the pharmacokinetics (PK) of RGH-338 in healthy subjects