Search for a trial

An open label study in two parallel groups, each receiving in a randomized, two period, cross-over design two single doses of Risperdal® Consta®, to explore the comparative bioavailability of two different batches of Risperdal® Consta® and the intra subject variability of one Risperdal® Consta® batch after intramuscular administration in healthy volunteers

Primary objectives:* To explore the comparative bioavailability between 12.5 mg of Risperdal® Consta® prepared from a 25 mg dose strength of Risperdal® Consta® EU-sourced, and 12.5 mg of Risperdal® Consta® prepared from a 12.5 mg dose strength…

The influence of Eye Movement treatment on imagery in psychosis

The objective of this study is to see wether the use of eye movement (EMDR) reduces the emotionality en vividness of imagery (mental images) above 'recall only'. This is a first study which may be the predecessor of a larger study, in…

Memantine Add-On Therapy to Clozapine

This proposal entails a proof-of-concept study into the neuropsychological effects of memantine augmentation in a random cross-over comparison to placebo, as add-on treatment to ongoing clozapine in severely mentally ill (SMI) patients with…

Tracing the origin of psychosis in schizophrenia - A repetitive TMS/neuroimaging study of frontostriatal interaction

The objective of this study is to directly test, in humans, the hypothesis that reduced prefrontral control leads to dysregulation of the striatum.

A double-blind, randomized, three-way cross-over trial to develop a pharmacologic challenge with ketamine.

The objectives are to assess the pharmacokinetic and pharmacodynamic effects of sub-anesthetic ketamine administration, to assess the optimal dose of ketamine and gender differences, to compare different oucome measures for psychomimetic symptoms…

The effect of FOsamprenavir/Ritonavir on the pharmacokinetics of a single-dose of the antipsychotic agent olanZApine (FORZA)

Primary objective: To evaluate the influence of fosamprenavir/ritonavir on single-dose pharmacokinetics of olanzapine in healthy volunteersSecondary objective: To evaluate the safety of fosamprenavir/ritonavir combined with single-dose olanzapine in…

A double-blind, randomized, placebo-controlled, five-way cross-over interaction trial to investigate the inhibitory effect of olanzapine on a THC-induced increase on the Positive and Negative Syndrome Scale

- To investigate whether olanzapine influences the (psychomimetic) effects of THC, in particular on the Positive and Negative Syndrome Scale (PANSS) - To further explore the pharmacologic basis of the THC model - To investigate the effects of…

An Open-Label Drug-Drug Interaction Study in Healthy Male Subjects to Explore the Effects of Single and Multiple Doses of JNJ-39393406 on the Pharmacokinetics of a Single Oral Dose of Midazolam

The purpose of this investigation is: • To examine the effect of single and multiple doses of the new drug JNJ-39393406 (the study medication) on absorption, metabolism and excretion by the body after single administration of the drug midazolam.• To…

A study to investigate the psychomotor and cognitive effects of alcohol when co-administered with GSK 1144814 or matching placebo in healthy subjects

To investigate whether the psychomotor and cognitive effects of alcohol are exacerbated by GSK1144814 in healthy subjects.

A Randomized, Open-Label, Single-Center, Crossover Study of the Potential Effects of Paroxetine on the Pharmacokinetics of a Single Dose of Paliperidone Extended-Release in Healthy Men

The primary objective of this study is to evaluate the effects of a CYP2D6 inhibitor, paroxetine, on the pharmacokinetics of a single dose of orally administered paliperidone ER. The safety and tolerability of the 3 mg tablet of paliperidone ER…

A Blinded, Placebo-Controlled, Randomized, Single Ascending Dose Study in Healthy Male Subjects to Investigate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of JNJ-37822681

The objectives for the study are:to investigate the safety and tolerability of JNJ-37822681 following single dose administrations in healthy male subjects.to investigate the plasma pharmacokinetic profile of JNJ-37822681 and metabolites after single…

An RCT on the effeciveness of a serious game for first episode psychotic patients and patients wit a developmental disorder with anxiety symptoms using cognitive bias modification (CBM).

The objective of this study is to examine whether a serious game using Cognitive Bias Modification is effective on anxiety symptoms and self stigma regarding patients with a psychotic disorder or a developmental disorder.

Randomized, double-blind, placebo-controlled, 3-way cross-over study to characterize the pharmacodynamics and pharmacokinetics of single-dose intravenously administered biperiden in healthy elderly male and female subjects

- Characterization of the CNS PD profile of IV administered biperiden- Characterization of the pharmacokinetic profile of IV administered biperiden- To confirm the plasma concentration-effect relationship of biperiden using population PK-PD modeling…

Efficacy of an anti-inflammatory diet on global functioning, gut microbiome and health of patients with schizophrenia spectrum disorder, bipolar disorder, Alzheimer*s disease or Parkinson*s disease: a randomized controlled trial

The primary objective is to investigate the potential effect of the AIDP on global functioning in patients with SSD, BD, AD, and PD. Secondary objectives are to investigate whether the AIDP has a beneficial effect on cognitive functioning, well-…

Paranoid behaviour and Threat evaluation in asylumseekers diagnosed with a psychotic disorder and experiencing paranoid delusions: A Phenomenological Qualitative Virtual Reality study

Objective: The main objective of this study is to discover how asylumseekers with a psychotic disorder who are experiencing paranoid delusions behave and evaluate threat in a virtual environment. Secondary objectives: To assess the suitability and…