35 results
To evaluate the effects of long-term intranasal oxytocin on social behaviour in children with PWS and to compare the effects of different doses and frequencies of oxytocin administration
To determine the prevalence and severity of ASA-related allergic reaction in SM patients.
Primary Objective:The primary objective in the current trial is to use graph theory to examine how the organization of the functional brain network may be altered by the administration of methylphenidate. The main question we intend to answer in…
To study the influence of systemic blood flow and mean arterial pressure on cerebral blood flow in patients undergoing on-pump cardiac surgery.
This study aims to determine to which degree the offered help - according to our treatment program - for familymembers and partners of murdered persons helps to treat complicated grief and PTSD (Murphy, 2006, Shear et al 2006) and to gain insight…
Investigate the effects of levocetirizine, diphenhydramine and placebo on cognitive and psychomotor functioning during controlled simulated diving in a recompression chamber in professional navy divers at 10 mt (2 bar) and 30 mt (4 bar).
Primary objective: to compare changes in endothelial function in patients with obesity related hypertension after 8 weeks of treatment with aliskiren, moxonidine and HCTZ.Secondary objectives: to compare changes in the following parameters in…
Primary Objectives:1. To compare the magnitude of baseline (or intrinsic) platelet reactivity between T2DM patients and healthy volunteers using multiple platelet function assays 2. To compare the magnitude of baseline (or intrinsic) platelet…
The aim of the study is to measure whether there is a difference in LDL cholesterol levels or the 24 hour ambulatory blood pressure in individuals at high risk of cardiovascular disease when the polypill is taken in the morning compared with the…
: The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects >=75 years of age with stable coronary artery disease (CAD)…
The goal of the current investigation is to test a new model that accounts better for results of pharmacological research. This model states that the cholinergic system underlies disengagement, and that the noradrenergic system underlies bias. Two…
The objective of this study is to test whether meat structure plays an important role in protein digestion, to maximise the amino acid availability and to stimulate the muscle protein growth in elderly people.
1) To assess insulin sensitivity and response in critically ill septic neonates and children. 2) To determine protein balance in septic, critically ill children at baseline and during a Hyperinsulinemic Euglycemic Clamp, while receiving standard or…
The aim of this study is to access the effect of low and high VT (ml/kg) on pulmonary and systemic inflammatory responses and the release of oxygen and nitrogen free radicals in the paediatric patient with and without ALI.
The primary objective of this study is to demonstrate non-inferiority by pharmacodynamic (PD) analysis of the prasugrel 5-mg maintenance dose (MD) in aspirin-treated subjects <60 kg with stable coronary artery disease (CAD) versus the…
The objective of the study is to investigate whether the Out-Of-Office BPM device of Microlife, the WatchBP O3, is comparable to the Spacelabs 90217 device at 24h BP measurement. Secondary objectives: To investigate whether the implemented features…
The primary objective is to investigate if there is an incremental inhibiting effect on MSNA by increasing dosage valsartan above the presently advised dosage. We hypothesize that there will be a further decrease in MSNA as compared to the MSNA…
This research proposal tests the hypothesis that an early asthma diagnosis is possible by using non-invasive biomarkers of oxidative stress/airway inflammation in exhaled air, venous blood and assessments of lung function (airway resistance by means…
In this study, the relationship between deficits within emotional memory and different typologies of psychopathy (impulsive vs. instrumental) will be examined. Furthermore, the current research concerns the influence (either positive or negative) of…
to investigate the relationship between acute psychological stress and perception of acid in the distal oesophagus in healthy volunteers and GORD patients.