144 results
The primary objective is to determine the safety and tolerability BCG vaccination followed by controlled human malaria infection; and to determine the protective efficacy BCG vaccination against a controlled human malaria infection.
The objective of this study is to investigate if CEC are elevated in SCD (and if they could therefore serve as a potential tool for assessing SCD activity), and what the relation of CEC is to the patients medical history and to specific laboratory…
We hypothesise that glaucoma patients with non-overlapping visual field defects have poorer binocular visual performance while performing complex visual tasks than would be predicted from their visual field. Knowledge on this topic is highly…
Primary objective is to investigate the effectiveness of ADAPT vs TAU on family functioning of veteran families as reported by the veteran. Secondary objective is to investigate the effectiveness of ADAPT versus TAU on family functioning as reported…
The aim of this study is to investigate how many patients with an early and/or chronic psychotic disorder reach personal recovery during follow-up and which determinants and processes influence personal, clinical, functional and societal recovery…
This study investigates the impact of a goal directed nutritional support protocol on sarcopenia in oncological patients undergoing an esophagectomy and secondary the incidence of anastomotic leakage and pneumonia, surgical infection and lenght of…
1) To investigate the effectiveness of Multi-family therapy (MFT) versus individual oriented treatment as usual (TAU) on end-of-treatment family functioning of veteran families, as reported by the veteran. TAU consists of supportive counselling or…
The primary objective is to compare differences between the communication strategies (personalized vs. standard, and personalized using iARR vs. personalized vs. CVD-free prognosis) on decisional certainty in patients with CVD at 1 month post-…
To assess the long-term safety and tolerability of 35 mg and 70 mg RVT-101 in subjects with DLB
To determine ex vivo neutrophil functions following exposure to therapeutic antibodies targeting inhibitory receptors expressed by neutrophils from RSV bronchiolitis patients. A secondary aim is to study soluble inhibitory receptors (such as LAIR-1…
Develop and implement a new functional MRI protocol for function mapping in young children.
The primary objective is to characterize the programming effects of Boston Scientific Vercise* PC System using the Deep Brain Stimulation Directional Lead for bilateral subthalamic nucleus DBS for the treatment of Parkinson*s disease in acute and…
Our objective is to find predictive biomarkers for disease progression in RVCL-S, a monogenetic small vessel disease, and to dissect disease mechanism to identify new treatment targets to improve health for RVCL-S patients, which may also serve as…
The purpose of this preclinical study is to obtain a quantitative measurement about the survival of human sperm cells when in contact with the Choice device. This in order to study safety and biocompatibility of the materials used for the Choice…
The objective of this study is to determine whether contralesional cTBS treatment modulates the interhemispheric imbalance in excitability or local or transcallosal inhibitory processes in the motor network of a population of stroke patients…
To assess the effectivity and feasibility of HCV RNA self-testing in reducing the time to diagnosis of HCV re-infection in MSM previously cured of an HCV infection, compared to the current diagnostic standard of care. To evaluate whether the uptake…
The aim of this study is to improve our understanding of the development of late effects after cancer treatment and reveal potential targets for intervention/prevention. Therefore we will investigate mechanisms behind the early ageing phenotype…
The primary objective of this study is to explore the diagnostic accuracy of MRDTI in the diagnostic management of acute and chronic SVT in a prospective diagnostic proof of concept study. The secondary objectives include optimizing MRDTI sequences…
We aim to identify diagnostic serum metabolite and protein biomarker signatures for early detection of cancer in asymptomatic high-risk population and prognostic biomarkers for selection of patients with poor prognosis.
- To establish the relationship between the use of deep neuromuscular blockade (NMB) with low pressure pneumoperitoneum (PNP) and the quality of recovery after RARP.- To establish the relationship between the use of deep neuromuscular blockade (NMB…