50 results
Primary Objectives:- Determine the effect of pulmonary vasodilatation on indexed cardiac output during simulated exercise.- Characterization of structural properties of small pulmonary arteries.Secondary Objectives: - Investigate the effect of…
The BAV study is a clinical and genetic study to unravel biomarker and imaging predictors of adverse outcome and to explore the pathogenetic basis of bicuspid aortic valves and it*s associated pathologies. We will also deliver insights in the…
Area of interest (study setting): Specific aims:Transient triggers and chronic riskfactors (case-crossover and casecontrol)(1) To investigate frequency and strength of association between transient physical andpsychological triggers and early-onset…
Primary Objective: to derive iPSCs from patients with a variety of diseases caused by genetic mutations or genetic predisposition to disease or of unknown origin. The cells will be propagated and differentiated into a variety of somatic cell types…
To evaluate the clinical usefulness of the VU-AMS in pediatric cardiology.To validate and improve the measures of stroke volume from the VU-AMS device in a clinical population. VU-AMS stroke volume measures will be compared with stroke volume…
To gain a better insight into the genetic factors that play a role in the etiology of the thoracic aortic aneurysm with the following specific aims:1. Study of specific geneitc factos that play a role in the pathogenesis of both syndromic and non-…
1. Validation - of an independent geneset - of TLA technology as a new DNA diagnostic test for complete sequencing of selected genes.2. The search for structural chromosome changes in patients with ROW disease who where tested negative for mutations…
Evaluate the effect of menarche and menstrual cycle on the QTc interval among girls with genetically-confirmed mutations causing LQTS type 1 (LQT1) and type 2 (LQT2).
The primary objective of this study is to identify mutations associated with the development of a bicuspid aortic valve. To this end the study will focus on genes important for aortic valve formation. As an extension of the primary objective, a…
The primary objective of the study is to determine whether exercise training exerts a long term effect on maximal exercise capacity, clinical events, sports participation, serum NT-proBNP and quality of life in adults with a systemic right ventricle…
In patients long-term after AVSD correction the objectives are:1) To evaluate myocardial function using novel echocardiographic techniques.2) To study atrial en ventricular size and function in relation to quantification of AVV function with the use…
The main objectives are 1) is to evaluate the prevalence of cardiac complications long-term after ASO by investigation of cardiac function as well as clinical outcome and to determine which factors (associated with life style or operative techniques…
To establish whether carriers of LMNA mutations have a hypercoagulable state compared to non-affected family members.
1. To evaluate the clinical usefulness of STIC with post-process rendering capability. Our goal is to investigate whether STIC gives more accurate information about a suspected cardiac anomaly, compared to conventional 2D ultracardiography.2. To…
The aim of this study is assessment of right ventricular function: a comparison between MRI and real-time 3-D echocardiography (RT 3-D echo). We have the following research questions: 1) Is assessment of right ventricular (RV) function with RT 3-D…
Our primary objective is to measurec glycocalyx volume with OPS imaging, before and after sublingual nitroglycerine-spray administration, in patients with premature atherosclerotic disease before the age of 40 years and a positiev family history for…
Routine evaluation of dyssynchrony in pediatric patients with cardiac disease is feasible using standard and novel echocardiographic techniques. The extent of cardiac dyssynchrony and its influence on cardiac function differs between groups of…
To identify an AAA associated genes by a functional candidate gene approach.The identification of an AAA associated gene will have several impacts on this high prevalent disease:1. It will improve our understanding of the molecular pathways involved…
Main objective of this study is to develop an MRI protocol from which regional PWV can be assessed. An automated image analysis tool, indispensable for fast, reproducible and observer-independent data processing will be developed. The technique will…
The primary aim of this study is to assess the applicability of RT3DE for the evaluation of left ventricular function in daily clinical practice of a pediatric cardiology service.