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Intracutaneous sodium storage in Intensive Care patients

To demonstrate differences in intracutaneous sodium storage between a control population, patients admitted after elective cardiothoracic surgery and septic patients.

Residual effects of Cushing*s syndrome after long term remission: Impact on adipose tissue, insulin resistance, exercise intolerance and increased risk of cardiovascular disease.

To identify some of the mechanisms in patients in remission of Cushing*s syndrome that contribute to the persistence of visceral obesity, systemic inflammation, insulin resistance, sarcopenia, a low muscle oxidative capacity and increased risk of…

The influence of ACTH on blood coagulation

The primary objective of this clinical controlled trial is to define the overall effect of adenocorticotropic hormone on coagulation parameters in patients with primary adrenal insufficiency (as diagnosed by their physician by previous short ACTH…

Facial and hand analysis, sleep apnea and speech in patients with acromegaly: a prospective study to investigate changes in craniofacial and hand characteristics, sleep apnea and speech during treatment and after remission.

To investigate the changes in facial- and hand analysis in patients with acromegaly as a result of medical treatment and pituitary surgery, and to investigate the changes in relational proportions between facial- and hand structures, incidence and…

Fully closed loop glucose Regulation; Evidence and Experience in real life

"The main objective of this trial is to assess long-term performance and obtain real-world experience with the bi-hormonal fully closed loop system (Inreda AP®)"

Disentangling the cause of atypical femur fractures associated with the use of bisphosphonates

Primary Objective: to identify risk factors and the underlying mechanism of AFFs by:- setting up a database with detailed information to define patients* characteristics.- building a biobank with urine and blood samples from these patients. -…

Exploring underlying mechanisms of paediatric growth disorders using human ex vivo growth plates.

The current study is designed to collect viable growth plate tissue of tall statured individuals that undergo percutaneous epiphysiodesis (PE). With this collected biomaterial we will be able to characterize dynamic changes in growth plate…

A Phase 1, Double-blind, Randomized, Placebo-controlled, Single Ascending Dose Study To Evaluate The Safety, Tolerability, And Pharmacokinetics Of Paltusotine In Healthy Subjects

In this study we will investigate how safe specific doses of the compound paltusotine are and how well these are tolerated when they are used by healthy participants.We also investigate how much of the compound is broken down and absorbed in the…

COVID-19 patients with severe or fatal outcome have a pre-existing state of immune-aging; exploring determinants of disease

To assess whether premature aging of both the innate and adaptive arms of theimmune system are associated with COVID-19 morbidity and mortality. Identify immune (andendocrine) parameters that might be of use in predicting disease progression and…

A Randomized, Double-blind, Placebo-controlled, Adaptive Study to Evaluate Symptom Improvement and Metabolic Control Among Adult Subjects With Symptomatic Hypoparathyroidism Treated With Recombinant Human Parathyroid Hormone [rhPTH(1-84)]

The primary objective is to test the hypothesis that rhPTH(1-84) treatment can result in superior improvements in the symptoms of hypoparathyroidism as assessed by the Hypoparathyroidism Symptom Diary (HPT-SD) symptom subscale compared with standard…