18 results
Determination of the (cost)effectiveness of the replacement of the expensive, risky and time-consuming food challenge test bythe Basophil Activation Test (BAT) for the diagnosis of an IgE-mediated cow*s milk allergy in children.
Objective: This protocol describes a framework that will be used to create different studies. The general primary and secondary objectives of this protocol are stated below:Primary objective: Investigate the effect of surgery on the position and…
Establishing efficacy and safety of the electrodes and implantable pulse generators (IPGs), which are used for deep brain stimulation (DBS) in patients with obsessive-compulsive disorder (OCD).
Primary objectives: - To examine how environmental exposures influence the prevalence, 5-year incidence and progression of cardiometabolic and chronic respiratory disease in the general population. - To determine the mediation effect of lifestyle…
This study has several objectives, in different (subsequent) study phases:• A1. Optimize and validate the technology of the VD to reach non-inferiority• B1. Demonstrate non-inferior performance and safety of the VD, for CE marking• B2. Demonstrate…
The aim of this study is to investigate the safety and efficacy of CAL-WR as primary and curative colon-preserving treatment for T1 colon cancer. Our primary endpoint is reduction of oncologic resections for low-risk T1 colon cancer. As secondary…
To examine the prevalence, risk factors and mechanisms of impaired health outcomes (short- and long-term medical and psychosocial effects and late effects) over time among a population-based sample of AYA cancer patients.Primary Objective: - To…
The main objectives of this project are:- To start a prospective observational cohort study of patients who have been diagnosed with CRC, small bowel and anal cancer and follow them from time of diagnosis until death.- To prospectively collect data…
First, to establish the yield of the currently propagated pancreatic cyst surveillance program, and second, to identify possible alternative surveillance strategies, which might be more (cost) effective.
The aim of this proof-of-concept study is to analyze the use of heart rate based variables using the Apple Watch:A) To predict Acute Chest Syndrome in patients hospitalized patients for painful crises;B) To predict painful crises in ambulant…
The goal of this study is to investigate which treatment(-s) lead to the best outcome by using existing variation of practice.
The main descriptive and analytic objectives are: Descriptive: To gather epidemiological evidence (prevalence, incidence) about the course of the mental, musculoskeletal and neurocognitive health (dependent variables) of…
The ultimate objective is to optimize pessary treatment for all patients with pelvic organ prolapse (POP). To reach this goal, we need to learn more about the mechanisms behind success and failure of pessary treatment. Previous research suggested…
Primary objective: Determine correlation between RFS parameters (5 independent signal characteristics) and non-invasive hemodynamic parameters (estimated left ventricular end diastolic pressure, left ventricular ejection fraction, left ventricular…
Primary Objective:The aim of this study is to evaluate whether the effect of PFMT on pelvic floor muscle strength could be detected via 4D ultrasonography strain measurements in patients with SUI. Secondary Objective(s)- To determine the…
In this study we look at how long it takes for the levels of certain hormones and hormone-binding proteins to normalize discontinuation of COC use, in particular corticosteroid-binding globulin.
The main aim of the current study will be to determine the metabolic fate of dietary protein. More specifically, the main aim is to assess the incorporation of protein-derived amino acids in a wide variety of organ tissues in vivo in humans.
Primary objective: 1. To validate the data quality and diagnostic accuracy of StrokePointer to detect LVO stroke among patients with a suspected stroke in the pre-hospital setting. Secondary objectives:1. To determine the user-…