3879 results
Focusing on disease-modifying rather than etiologic mechanisms may accelerate the development of novel therapies and complement current research initiatives on causative mechanisms and curative therapies.
Education on guidelines, combined with quality targets within the accreditation procedure improves quality of antibiotic prescribing
We hypothesized a beneficial effect of IUI in couples with an isolated cervical factor. Furthermore we hypothesized that the post-coital test can identify those couples who would benefit from IUI without ovarian hyperstimulation.
Salmeterol has an inhibitory effect on both allergen and allergen/LPS induced inflammation in asthmatics while on maintenance treatment with low dose corticosteroids.
1-2 intramuscular injections with 100 mg dexamethason in persons without arthritis but with elevated serum levels of rheumatoid factor and or anti-CCP will lead to a reduction in antibody concentrations after 6 months and possibly to a lower…
Patients with Type 2 diabetes have been shown to have an increased risk for developing cancer, especially obesity related cancers. There is some evidence that within the class of sulfonylureas there is a difference in cancer risk; gliclazide could…
Different prevention strategies are used internationally to prevent Early-onset Group B haemolytic streptococcus infection (EOGBS). However, none of the preventive EOGBS strategies in place at present result in the complete prevention of EOGBS,…
This international, multi-centre, double blinded, placebo-controlled, randomised clinical trial will be performed: To assess the effectiveness of one year of alternate days Levamisole treatment in a dose of 2.5 mg/kg in the prevention of relapses…
We postulate that exhaled molecular profiling obtained from ‘breathprints’ by electronic nose: 1. Is associated with the level of asthma control and; 2. Is associated with an inflammatory profile in induced sputum and blood in steroiddependent…
Muscle hypoxia, either chronic or intermittent (exercise-induced), is responsible for the altered muscle oxidative phenotype in chronic obstructive pulmonary disease and chronic heart failure through modulation of the regulatory molecules PGC-1/…
Antireflux surgery is one of the most common major operations performed in pediatric patients. Most studies on the outcome of antireflux surgery in children are limited to retrospective data, case reports or are based solely on symptoms. A…
the aim of this study is to compare two strategies that present a large contrast in the stimulation dosage, i.e. a high dosage of stimulation versus a low dosage of stimulation. Our study is designed to objectively compare the ongoing pregnancy rate…
Addittional training of teachers will result in greater effect-sizes for a school-based child intervention program for childhood behavior problems. Assessment of stepped-care child, teacher and parent intervention.
Submucous fibroids are known to be related to heavy menstrual bleeding (HMB), dysmenorrhea and fertility problems. Transcervical resection of fibroids (TCRM) is a widely implemented treatment for submucous fibroids, to be precise FIGO PALM-COEIN…
1. To determine the reproducibility and sensitivity of the Energy Cost of Walking test (ECWT) in boys with Duchenne muscular dystrophy, in comparison with the reproducibility and sensitivity of the 6-Minute Walk Test (6MWT); 2. To evaluate the 1-…
The primary objective of this study is to determine whether thrombectomy combined with ischemic postconditioning after PCI leads to a smaller myocardial infarction compared to standard therapy.
1. The intervention 'Happiness Route' is effective in promoting positive mental health in comparison to a control condition that consists of optimized care-as-usual; 2. In comparison to the control condition, the intervention '…
The bioavailability and effectiveness of vitamin K tablets and solution are comparable.
In primary prostate cancer patients, the exisstence of lymph node metastases is associated with developmment of distant metastases and negatively associated with cancer-specific survival. The performance of an extended lymph node dissection (ePLND…
Our primary outcome is change in suicide ideation in patients. We hypothesise that, as a result of the improved skills and confidence of healthcare professionals in the experimental condition due to the intervention, suicidal patients are better…