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The effects of intravenous TRH administration on brown adipose tissue activity in healthy, lean men.

To investigate whether BAT tissue can be activated by intravenous administration of TRH. Secondary objectives are to determine whether intravenous TRH increases the degree of cardiovascular sympathetic stimulation and the response of skin…

Effect of Multiple healthy donor intestinal microbiota infusions on non Alcoholic Steatosis Hepatis (NASH) and vascular function in obese subjects

In this study we would like to investigate whether repetitive allogeneic (lean donor) fecal transplantations can reduce liversteatosis and if so which (small) intestinal bacteria cause this inflammation in the liver resulting in subsequent chronic…

Viscosity of PMMA Bone Cement in Percutaneous Vertebroplasty for Osteoporotic Vertebral Compression Fractures: A Randomized Controlled Trial

Establishment whether usage of high viscosity PMMA bone cement in PVP for OVCFs leads to a reduction in leakage incidence compared to usage of conventional (low-medium) viscosity PMMA bone cement in PVP for OVCFs.Since evidence is scarce or…

Standardized versus individualized growth hormone treatment of short children born small for gestational age: Effects on short-term and long-term efficacy, long-term psychosocial development, glucose metabolism and body composition.

The primary objective of this study is to assess the effect of individualizing the growth hormone dose versus standard treatment with 1 mg/m2/day on adult height and the first and five year growth response. Secondly, we want to assess the long term…

A randomized, double-blind placebo-controlled, multicenter phase III study in patients with advanced carcinoid tumor receiving Sandostatin LAR and RAD001 10 mg/Day or Sandostatin LAR and Placebo

To determine whether treatment with RAD001 10 mg/d plus Sandostatin LAR® prolongs the progression free survival (PFS) compared to treatment with Sandostatin LAR® alone in patients with advanced carcinoid tumor.

Standardized versus individualized growth hormone treatment of short children born small for gestational age: Effects on short-term and longterm efficacy, long-term psychosocial development, glucose metabolism and body composition.

The primary objective of this study is to assess the effect of individualizing the growth hormone dose versus standard treatment with 1 mg/m2/day on adult height. Secondly, we want to assess the first and five year growth response, the long term…

The effect of moderate alcohol consumption on a human in vivo model of low-grade systemic inflammation in young, normal-weight men

Primary objective: To explore whether prolonged moderate alcohol consumption affects in vivo cytokine response after a low dose of LPS in young, normal-weight men.Secondary objectives: To explore whether prolonged moderate alcohol consumption-…

The effect of acute moderate alcohol consumption after a psychological stressor on the stress response in men

Primary objectives: Stress response: To determine whether acute alcohol consumption shortly after a psychological/mental stressor attenuates the stress response recovery.Cholinergic status: To determine whether prolonged moderate alcohol consumption…

Role of brown fat and skeletal muscle in post-prandial clearance of triglycerides during and after cold exposure

1. To examine the effect of cold on post-prandial triglyceride metabolism using a standardized meal test during and after cold exposure 2. To examine the relationship between cold-induced brown adipose tissue activity and the changes in…

A study comparing the effect and safety of once weekly dosing of somapacitan with daily Norditropin® as well as evaluating long-term safety of somapacitan in a basket study design in children with short stature either born small for gestational age or with Turner syndrome, Noonan syndrome, or idiopathic short stature

This study has been transitioned to CTIS with ID 2023-506927-27-00 check the CTIS register for the current data. Primary objectiveThe primary objective of this study is to confirm non-inferiority of once-weekly somapacitan compared with once-daily…

Growing up with the Young Endocrine Support System (YESS!): innovative e-technology to improve transition from paediatric to adult care.

Primary Objective: -To investigate whether there is a difference in the Self-management and Transition to Adulthood with Rx (treatment) (STARx) questionnaire score at t=12 months minus the score at t=0 in group YT compared to group O.Secondary…

A phase III multi-center, randomized, open-label study to evaluate the efficacy and safety of Lutathera in patients with Grade 2 and Grade 3 advanced GEP-NET

This study has been transitioned to CTIS with ID 2023-507443-10-00 check the CTIS register for the current data. The pivotal Phase III NETTER-1 study showed that Lutathera with best supportive care (30mg octreotide long-acting) provided a…

Effect of blue light from electronic devices on melatonin and sleep/wake rhythms in high school children

We will determine in a prospective cohortl study, differences between frequent screen users and infrequent screen users in sleep onset time, wake-up time, mid-sleep time, sleep duration, body mass index and melatonin onset. In the randomized cross-…

A randomized, double blind (sponsor open), comparative, multicenter study to evaluate the safety and efficacy of subcutaneous belimumab (GSK1550188) and intravenous rituximab coadministration in subjects with primary Sjögren*s syndrome.

To evaluate the safety and efficacy of subcutaneousbelimumab (GSK1550188) and intravenous rituximab coadministrationin subjects with primary Sjögren*s syndrome.