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Neurocognitive effects of low-grade glioma resection in eloquent areas

1) Evaluating the effect and recovery of glioma surgery in eloquent areas on cognitive functioning.2) Examining the effec tof glioma surgery in eloquent areas on quality of life.3) Examining the effect of gliomas in eloquent areas on the…

Implantology and Sjögren*s syndrome: a multicenter prospective cohort study

To investigate changes in marginal peri-implant bone loss and the clinical performance of dental implants in SS patients compared to implants in healthy patients.

Mandibular Advancement Device (MAD) therapy in edentulous patients with obstructive sleep apnea: dental implant fixed MADs vs. CPAP.

The main purpose of this pilot study is to assess the feasibility and potential efficacy of implant retained mandibular advancement device (MAD) therapy on a small scale in edentulous patients with mild to moderate OSA in comparison to CPAP therapy…

Oral function after oncological intervention, reconstruction and rehabilitation in the oral cavity

The aim of this study is to objectively and subjectively characterise different aspects of oral function for malignancy of the oral cavity.

The effects of propranolol on fear of tooth removal: A randomized, placebo-controlled, double-blind, parallel design trial

The aim of this study is to determine the effects of propranolol on patients* crucial fear-related memories and dental trait anxiety in those undergoing surgical removal of one of their teeth or molars. The hypotheses that are tested are that…

The efficacy of Cone beam CT compared to panoramic radiography for removal of impacted mandibular third molars: a randomized controlled trial*

To evaluate the efficacy and cost-effectiveness of CBCT imaging compared to panoramic radiography prior to removal of third molars in reducing patient*s morbidity.

Bèta-TCP (bèta-tricalcium phosphate) as a bone substitute in patients undergoing repair of the alveolar cleft in CLP(Cleft Lip Palate) patients.

This current study aims to investigate the use of Curios bèta-TCP, a synthetic tricalcium phosphate for repair of the alveolar cleft in patients with clefts of lip, alveolus and palate.The specific properties of Progentix TCP result in optimal and…

A multi center, prospective, randomized controlled trial comparing cervical arthroplasty to anterior cervical discectomy and fusion (ACDF) for the treatment of cervical degenerative disc disease.

The primary objective of this investigation is to evaluate the performance of the DISCOVER Artificial CervicalDisc in the treatment of cervical disc disease by measuring the function assessed via Neck Disability Index(NDI) and neurological function…

Chromosomal instability as indicator for the treatment of progressive mucosal lesions of the oral cavity: a prospective study.

The aim of this prospective study is the prevention of progression of premalignant lesions to invasive head and neck cancer by modifying the out-patient follow up and patient management.

Taste, Speech and oro-facial relations following partial tongue reduction: A single-center, longitudinal, functional outcome study in patients with Beckwith-Wiedemann Syndrome that have undergone tongue reduction surgery

The aim of this study is to investigate the long-term outcomes in patients with BWS that have been surgically treated at our institution with the help of simple, non-invasive, objective study tools. We hope to gain valuable information regarding the…

A prospective study to determine the value of chromosomal instability in selecting treatment of head and neck mucosal lesions.

Primary objectives:(1) Prevent progression of precursor lesions of the head and neck mucosa by treating selected lesions at risk for malignant outgrowth(2) Demonstrate that the detection of chromosomal instability (CIN) is indeed a powerful tool to…

Conventional tonsillectomy versus outpatient CO2-lasertonsillotomy in adult patients; a randomised controlled trial

The purpose of this study is to demonstrate the effectiveness of treatment using the CO2-laser in one selected group of patients compared with a classical tonsillectomy. We also compare peri-operative en post-operative morbidity, pain, complications…

Rare Facial Clefts: Physical and Psychological Outcome and it's Implications, addendum: "Fysical features of patients with proven genetic mutation (EfnB1) and clinical diagnosis of Craniofrontonasal Dysplasia"

zie bovenstaand

The effectiveness of a microscope during apical surgery; a prospective randomized controlled blinded clinical trial.

The objective of this study is to assess whether or not apical surgery that is carried out with the help of a microscope has a higher success rate than apical surgery without the use of a microscope. No RCT is found in present literature (Del Fabbro…

Peri-implantitis, implant loss and osteoradionecrosis in oral cancer patients

Primary Objective: What are the consequences of irradiation for the human jaw bone and oral mucosa on a macroscopic, microscopic and molecular level?Can possible prognostic factors be identified for the occurrence of peri-implantitis, dental implant…

Long-term stability and survival rates of a novel Oticon Medical bone conduction device implant

The overall aim of the study is to investigate the Ponto wide implant considering; initial implant stability, stability over time, skin reaction and long term success when loaded at 3 weeks post surgery. Patients* quality of life improvements…

A Randomised Controlled Clinical Trial comparing the results of the Immediate Loading (within 48 hours) of Mandibular Overdentures supported by either 2 standard Straumann dental implants or 4 Mini Dental Implants (MDIs).

In this randomized controlled clinical trial we aim to apply the-already investigated-concept of immediate loading protocol and examine the performance of implant-retained overdentures using 2 SLAactive Straumann implants connected by bar ( Contol…

Cervical spine movement, before and after anterior cervical discectomy (ACD).
ACD, pure intervertebral discectomy (1) compared to intervertebral discectomy followed by implantation of an intervertebral disc prosthesis (2) in patients with a radicular syndrome. A randomised study

Objective of the study is to verify whether the movement pattern after anterior cervical discectomy normalises, in case of implantation of a cervical disc prosthesis.

Effectiveness of postoperative radiotherapy in patients with oral or oropharyngeal squamous cell carcinoma and histologically confirmed single ipsilateral lymphnode metastasis (pN1)

To determine the optimal therapy for patients with pT1-2 pN0 oral and oropharyngeal cancer

Bilateral Cochlear Implantation Benefits in Adult Users of the HiRes 90K Bionic Ear System

1) Compare a group of bilateral users to a unilateral control group (between-subject design)2) Compare unilateral use to bilateral use after sequential implantation (within-subject design)3) Compare simultaneous bilateral implantation to sequential…