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Diagnostics and mechanisms of titanium allergy

Primary Objective:Pilot study: Selection of the titanium derivatives which are capable of penetrating the skin, and thus can be used in the full study as patch test materials.Full study: To compare the results of three different diagnostic tests…

Evaluation of different wound dressings in the treatment of children with spoke injuries

To study wether a biodressing impregnated with polyhexamethylene biguanide in the treatment of spoke injuries in children could give a reduction in pain during the treatment compared to the standard treatment with wound dressing impregnated with

Wireless Micro Current Stimulation: adjunctive therapy for hard-to-heal chronic wounds * a double-blind, placebo controlled trial

Our aim is to determine whether Wireless Micro Current Stimulation accelerates wound healing in hard-to-heal chronic wounds as compared to standard wound care treatment by conducting a double-blind, placebo controlled trial.

A randomized, double-blind, placebo-controlled, parallel group study evaluating efficacy and safety of QAW039 in the treatment of patients with moderate to severe atopic dermatitis (CQAW039X2201)

Primary objective: To evaluate the efficacy of once daily doses of QAW039, as measured by EASI after 12 weeks of treatment, relative to placebo, in adult patients with moderate to severe AD. To evaluate safety and tolerability.Secondary objectives:…

The effect of Staphefekt on the skin microbiome, including Staphylococcus aureus, in patients with atopic dermatitis.

To retrieve (in vivo) data about the effect of Staphefekt on the microbiome, including Staphylococcus aureus, and on disease severity in patients with atopic dermatitis.

A first-in-human study to evaluate safety and tolerability of repeated topical administrations of BPR277 ointment in healthy volunteers, and safety, tolerability, and preliminary efficacy of multiple topical administrations of BPR277 in patients with atopic dermatitis and Netherton syndrome (CBPR277X2101)

Primary: (part 3) Potential of BPR277 1% ointment b.i.d. to improve the clinical severity of lesional skin in the majority of NS patients at end of treatment versus baseline of >= 2 points, dose range and regimen relationship on clinical…

A Phase 2, Multicenter, Randomized, Double blind, Parallel group, Placebo controlled Study Evaluating the Safety and Efficacy of Treatment with Ustekinumab or Golimumab in Subjects with Chronic Sarcoidosis

See above

A Phase III, randomised, double blind, placebo controlled, parallel group study, to evaluate the safety and efficacy of subcutaneous implants of afamelanotide (16 mg) in patients suffering from polymorphic light eruption (PLE).

Primary Objective - To determine if afamelanotide can reduce the severity of PLE related pruritis.Secondary Objectives- To determine if afamelanotide can reduce the frequency of PLE episodes;- To determine if afamelanotide can reduce the duration of…

A randomized, double-blind, placebo controlled, parallel group, proof of concept study evaluating the efficacy, safety, pharmacokinetics and pharmacodynamics of QGE031 in the treatment of patients with moderate to severe atopic dermatitis (CQGE031X2201)

Primary: To demonstrate the efficacy of QGE031 relative to placebo at 12 weeks in patients withatopic dermatitis (AD) as assessed by Eczema Area and Severity Index (EASI).Secondary: efficacy assessed by Investigator Global Assessment (IGA, 12 weeks…

Evaluation of a newly developed spineboard in anaesthetized patients.

We want to study whether there is a difference with respect to the pressure exerted onto the body when using a normal spineboard and a newly developed spineboard, related to the level of consciousness of the volunteer. Also the experienced comfort…

The Effects of Guided Imagery on Pain Management, Pre-operative Anxiety, and Recovery in Burn Wound Patients scheduled for Corrective or Reconstructive Surgery: a Randomized Controlled Pilot Study.

Goals:1.To estimate the effect size for our primary and secondary outcome measures, allowing us to perform a more reliable power estimate for the actual trial.The primary objective of this pilot study is to determine whether a non-pharmacological…

The EDEN international study on the prevalence of contact allergy to fragrances

To test the feasibility of an intended large scale fragrance-allergy prevalence study in the population of the north of the Netherlands and to make a more reliable estimate of the prevalence in the population for poweranalysis of the intended large…

Measurement of cytokines, bloodflow and erythema after shear- force application of the skin in patients with Diabetes Mellitus

1. The objective of this study is to aquire knowledge about the development of reactive hyperaemia and inflammatory responses of the skin after shear- force and pressure loading. We want to investigate if patients with diabetes type 2 will develop…

Facial and hand analysis, sleep apnea and speech in patients with acromegaly: a prospective study to investigate changes in craniofacial and hand characteristics, sleep apnea and speech during treatment and after remission.

To investigate the changes in facial- and hand analysis in patients with acromegaly as a result of medical treatment and pituitary surgery, and to investigate the changes in relational proportions between facial- and hand structures, incidence and…

A 52-week, multicenter, randomized, double-blind study of subcutaneous secukinumab to demonstrate efficacy as assessed by Psoriasis Area and Severity Index at 16 weeks of treatment compared to ustekinumab and to assess long-term safety, tolerability and efficacy in subjects with
moderate to severe plaque psoriasis (CAIN457A2317)

Primary: To demonstrate the superiority of secukinumab in subjects with moderate to severe plaque psoriasis based on the proportion of PASI 90 responders at Week 16, compared to ustekinumab.Secondary: To demonstrate the superiority of secukinumab in…

Effect of postoperative negative pressure wound therapy (Prevena TM) in clean closed surgical incisions on the incidence of wound dehiscence in low and high risk patients: a rondomized controlled pilotstudy.

The aim of this study is to compare the effect of a postoperativenegative pressure dressing (Prevena (TM) IMS) with a standardwound dressing (care as usual) in clean closed surgical wounds on the prevention of wounddehiscence in low riks and high…

Is lowering of shear and friction (cost)effective for prevention of pressure ulcers? A multicenter, prospective, controlled randomized clinical trial in Dutch nursing homes.

Analyze whether application of a theoretical reasoned and tested system with test subjects is preventive and costs effective.

Long term clear skin maintenance treatment optimization in patients with moderate to severe chronic plaque psoriasis: A randomized, multicenter, open-label with blinded-assessment, comparative, 52 week study to evaluate the efficacy, safety and tolerability of secukinumab 300 mg s.c.

This study will assess if a more prolonged dose interval (every 6 weeks compared to every 4 weeks) will allow psoriasis patients who achieveclear or almost clear skin after 24 weeks of secukinumab treatment - Psoriasis Area and Severity Index (PASI…

Effect of a negative pressure dressing (Prevena TM) on the prevention of wound dehiscence in clean closed surgical incisions: a rondomized controlled trial.

The aim of this study is to compare the effectiveness of a negative pressure dressing (Prevena (TM) IMS) with a standard wound dressing (care as usual) in clean closed surgical wounds on the prevention of wounddehiscence in patients, undergoing an…

A randomized, double-blind, placebo-controlled study to assess the pharmacodynamics, safety, tolerability and efficacy of omiganan BID in patients with mild to moderate atopic dermatitis

Primary Objective- To assess efficacy and pharmacodynamic effects of topical omiganan BID Secondary Objectives- To assess safety and tolerability of topical omiganan BID