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A new approach to measure vaginal microcirculation

To investigate the feasibility of SDF imaging and spectrophotometry of the vaginal wall.

Effects of local oestrogen on vaginal microcirculation in the treatment of vaginal atrophy

1. To examine and describe the vaginal microcirculation in patients with VA in comparison to patients without VA2. To examine and describe the effect of treatment with local oestrogen on the vaginal microcirculation.

Effects of pelvic organ prolapse and vaginal prolapse surgery on vaginal microcirculation

1. To investigate the intra- and inter-observer agreement in the assessment of vaginal capillary density using SDF imaging. 2. To investigate whether between patients with and without pelvic organ prolapse (POP) and in the compartment with and…

Laparoscopic versus open abdominal sacral colpopexy for vaginal vault prolapse.
A comparison of effectivity, quality of life and costs.

OBJECTIVE: It has been estimated that one in nine women will undergo a hysterectomy during lifetime. Up to 10% of these women will subsequently need surgical repair for vaginal vault prolapse thereafter. Sacral colpopexy is a generally applied…

Evaluation of multiplex PCR for diagnosing bacterial vaginosis and candidiasis in fluor vaginalis

The aim of this pilot study is validate the multiplex PCR for bacterial vaginosis and candidiasis on the basis of Nugent score, Amsel criteria, clinical diagnosis of candidiasis and culture before and after treatment. Besides that we will measure…

A phase 2, randomized, double-blind, parallel-group study to assess the pharmacodynamics, safety/tolerability and efficacy of topical omiganan in patients with usual type vulvar intraepithelial neoplasia

Primary Objective• To explore the pharmacodynamic effects of topically applied omiganan • To explore the treatment effect of omiganan compared to placebo in uVIN patients Secondary Objectives• To assess safety and tolerability • To explore the…

THE VULVA STUDY: Online psychotherapy and TENS@HOME for patients with provoked vulvodynia.

Overall we aim for a more effective treatment of provoked vulvodynia with less relapse, taking into account the patients autonomy as an important key to long term cure. Primary outcome: Decrease of pain during (attempt to) penetration, measured by a…

5-AMINOLEVULINIC ACID PHOTODYNAMIC THERAPY FOR THE TREATMENT OF PREMALIGNANT DISORDERS OF THE VULVA

Primary objective: To assess the efficacy of low dose rate light fractionated aminolevulinic acid-Photodynamic Therapy (ALA-PDT) for treatment of VLS and HSIL. Clinical and histological response. Secondary objectives: Tolerence of ALA-PDT by…

Pelvic organ prolapse, self-image and acceptance

Primary Objective: 1. To determine if and in what way the pelvic organ prolapse influences the sexual function and the self-image of the patient2. To compare the POP group and the control group on level of sexual function and (sexual) self-concept…

Sentinel lymph node procedure in patients with recurrent vulvar squamous cell carcinoma. A multicentre observational study.

The primary objective is to investigate the safety of replacing complete IFL by the SLN procedure in patients with local recurrent vulvar squamous cell carcinoma without suspicious groin lymph nodes.

A phase 2, randomized, vehicle-controlled, double-blind study to explore the efficacy, pharmacodynamics and safety of topical ionic contra-viral therapy (ICVT) comprised of digoxin and furosemide in HPV-induced genital lesions of immunocompromised and immunocompetent patients.

Primary Objective• To explore the pharmacodynamics of the ionic contra-viral therapy CLS003 in immunocompromised and immunocompetent patients with benign and premalignant HPV-induced genital lesions.• To evaluate clinical efficacy of CLS003 compared…