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Anticoagulants for Living Fetuses in women with recurrent miscarriage and inherited thrombophilia; ALIFE2 study

To evaluate the efficacy of low molecular weight heparin (LMWH) in women with inherited thrombophilia and recurrent miscarriage on live birth.

Immunological causes of recurrent miscarriages.

Does humoral and/or cellular rejection play a role in recurrent miscarriage of unknown etiology?Can biomarkers of humoral and/or cellular rejection be used for the detection of patients who are likely to suffer a miscarriage in a next pregnancy?

Levothyroxine for euthyroid women with recurrent miscarriage and positive TPO antibodies: a randomized controlled trial

First objective: To assess improvement in live birth rate after levothyroxine supplementation. Secondary objective: 1) to test the hypothesis that levothyroxine lowers the risk for miscarriage and preterm birth 2) to test the hypothesis that…

Mifepristone and misoprostol versus misoprostol alone for uterine evacuation after early pregnancy failure: a pilot study

Th**is study will compare sequential mifepristone and misoprostol (*M&M*) treatment versus misoprostol treatment alone, which is currently the standard medical treatment in the Netherlands.

What should be done in women with an incomplete evacuation of the uterus after treatment with misoprostol for miscarriage? An analysis of costs and effects.

To assess costs and effects of curettage versus expectant management in women with incomplete evacuation of a miscarriage, as diagnosed with sonography, after misoprostol.

Genetic immunological causes of recurrent miscarriages;
'HLA sharing as a cause of recurrent miscarriages'

Does HLA sharing in couples with recurrent miscarriage play a role in recurrent miscarriage of unknown etiology?

Assessment of Capnography in Monitoring Patients during Deep Sedation with Propofol

At the Centre for Contraception, Sexuality and Abortion Leiden, abortion procedures are performed under deep sedation using Propofol. Patient*s monitoring is performed by nurses qualified in patient sedation management, using pulse oximetry and…

The Randomised Uterine Septum Transsection Trial

This study will answer the question whether surgical intervention (metroplasty) in women with recurrent miscarriage and/or subfertility and a septate uterus will improve their reproductive outcome.

Recurrent miscarriages and the subsequent risk of cardiovascular disease.

Is recurrent miscarriage an independent risk factor for an increased cardiovascular risk?

Towards a new technique for pre-implantation genetic embryo screening in IVF, pilot phase

The objective of this study is to evaluate a new and less invasive method of PGS. The new PGS technique will analyse a nucleus of a blastomere that was obtained by nuclear extraction rather than by biopsy of a whole blastomere.

A study of the effects of a novel ovarian stimulation regimen on embryo aneuploidy rates in IVF, and the impact of aneuploidy on implantation, as assessed in an in vitro model.

In this study we aim to compare the effect of two different ovarian stimulation protocols on embryo quality in a group of women of 39 years or younger, in a prospectively randomized controlled trial. PGS will be performed to assess chromosomal…

Modulation of the cardiovascular and immunologic characteristics by aerobic exercise in women with recurrent miscarriage

To study the effects of physical training on vascular, endothelial and immunologic functioning in women with recurrent miscarriage; results are compared with women who have never been pregnant (nulligravid controls) and women who have a history of…

First trimester progesterone therapy to reduce miscarriages in women with a history of unexplained recurrent miscarriages: A randomised, double blind, placebo-controlled, multi-centre trial.

To test the hypothesis that in women with unexplained recurrent miscarriages, progesterone started as soon as possible after a positive pregnancy test ) and continued to 12 weeks of gestation, compared to placebo, increases live births beyond 24…

Reasons for induced abortion

The main objective of this study is to analyze women's decision making processes regarding an unintended pregnancy in order to improve the counseling (in abortion and reproductive health clinics) for these women.

NATURAL KILLER CELL PHENOTYPE IN UNEXPLAINED RECURRENT MISCARRIAGES

The main goal of this study is to analyse NK cell phenotype in women with unexplained recurrent miscarriage in relation to their physical health.

Exercise training in women with unexplained recurrent pregnancy loss to optimize receptive endometrial NK cell population and function

Is moderate exercise training for 12 weeks in women with RPL improving CD56bright eNK cell population and function?

Mifepristone and misoprostol versus misoprostol alone for uterine evacuation after early pregnancy failure: a randomized double blind placebo-controlled comparison (Triple M trial)

This study will compare sequential mifepristone and misoprostol treatment versus misoprostol treatment alone, which is currently the standard medical treatment in the Netherlands.