83 results
The aim of this study is to determine whether children between 5-17 years born to women with an autoimmune disorder and prednisone use during pregnancy have chronically elevated cortisol levels compared to children born to women with an autoimmune…
Primary objective: to determine the incidence and location of thrombi in the umbilical venous catheter route during and after umbilical catheterization and in the same route in infants without umbilical catheters. Secondary objectives:A. to…
The next questions will be addressed in the present study: 1. Do moderately preterm infants differ in development and attention and concentration capacities from a term and very preterm infants during the first years of life? 2. Do attention and…
To determine whether administration of exogenous surfactant using a minimally-invasive technique improves outcome in preterm infants 25-28 weeks gestation treated with continuous positive airway pressure (CPAP).
The APOSTEL-VI study will assess whether a cervical pessary prolongs pregnancy in women who have been admitted for threatened preterm labor with a positive fibronectin test, but remained undelivered. Furthermore we will study whether a cervical…
To assess whether a higher prophylactic platelet transfusion threshold is superior to the lower thresholds in reducing the proportion of patients who experience a major bleed or death up to study day 28.
To determine whether increased calcium and phosphate intake (2005 group) resulted in improved Bone Mineral Content (BMC) and Bone Mineral Density (BMD) compared to the group with less calcium and phosphate intake (2004 group) at the age of 8-10…
The primary objective of the SafeBoosC trial is to examine if it is possible to stabilise the cerebral oxygenation of extremely preterm infants (gestational age < 28 wks) during the first 72 hours of life through the application of cerebral…
To assess the effects of Cognitive Behavioral Therapy (CBT) in pregnant women with symptoms of anxiety or depression on the child*s behavioral/emotional problems. In addition, we aim to study its effects on the child*s development, maternal mental…
The primary objective of this study is to evaluate neurophysiologic changes of the pain centres of the brain (the differences in particular in the thalamus, primary and secondary somatosensory cortex, insula, anterior cingulate cortex and the motor…
The primary objective of this study is to compare the level of stress and comfort of preterm infants when sedation is given during the MIST procedure compared to no sedation.
In this multicenter trial we compare resuscitation of preterm neonates with either 5 cm H2O PEEP or 8 cmH2O PEEP. We think resuscitation with 8 cmH2O PEEP results in a better outcome compared to resuscitation with 5 cmH2O PEEP.
Evaluation of the effects of intravenous lipid and extra amino acid supplementation from birth onwards to very low birth weight infants on amino acid turnover and protein accretion. As secondary objectives the safety, energy expenditure and short-…
The objective is to study the effectiveness of the Triple P program compared to a control group, for parents and their NICU-graduates with emotional and/or behavioral problems. Effectivenes concerns children's problems, parents' parenting…
To evaluate the bowel function, quality of life and nutritional status in adolescents/adults who experienced an episode of NEC at neonatal age.
This study will answer the question if (repeated) abdominal amnioninfusion after midtrimester PPROM with associated oligohydramnios improves perinatal survival and prevents pulmonary hypoplasia and other neonatal morbidities. Moreover, it will…
1. To describe the development of the nature of the immune system in early life in a profile of cytokines, chemokines and adipokines. 2. To evaluate less invasive methods like the use of saliva or less demanding methods like the use of dried bloods…
In the present proposal, we aim to answer whether antenatal allopurinol administration does reduce hypoxic-ischaemic encephalopathy in neonates exposed to intra-uterine asphyxia.
The project aims to gain more insight in the process of bonding between parents and prenature infants, to validate a screening instrument that can be easily adopted in maternity wards of (general) hospitals to detect parents and children at risk for…
To optimize the quality and cost-effectiveness of care for jaundiced neonates in the Isala Klinieken.