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Inguinal or Ilio-inguinal Lymphadenectomy for Patients With Metastatic Melanoma to Groin Lymph Nodes and no Evidence of Pelvic Disease on PET/CT Scan - A Randomised Phase III Trial (EAGLE FM)

This study aims to provide a more rational evidence base for appropriate management for metastatic melanoma in the groin LNs, through assessing the effect of the addition of ipsilateral pelvic lymphadenectomy on patient disease-free survival (DFS),…

Improving quality of survivorship for breast cancer-related lymphedema by lymphatic microsurgery: A randomized controlled trial

To assess the effectivity of LVA on arm volume in comparison to standard therapy after 12 months.

Effectiveness and cost-effectiveness of lymphaticovenous anastomosis for cancer patients who suffer from chronic peripheral lymphedema

Primary Objective:The primary objective is to assess the efficacy of LVA surgery in comparison to sham procedure in patients with cancer related lymphedema in the context of improvement of Lymph-ICF score at 12 and 24 months follow up. Secondary…

Improving the quality of life of patients with breast cancer-related lymphedema by lymphaticovenous anastomosis (LVA): A randomized controlled trial

The primary objective of this randomized controlled trial is to study the effectiveness of lymphaticovenous anastomosis (LVA) compared to complex decongestive therapy (CDT) in terms of health-related quality of life (HRQoL). Secondary objectives are…

Validation of a Magnetic Resonance Lymphography protocol in upper extremity lymphedema and healthy subjects*

To determine the feasibility and applicability of the MRL protocol by comparing the images in upper extremity in patients with secondary lymphedema and healthy subjects, and to assess differences in the lymphatic system between the lymphedema…

Deep inferior epigastric perforator flap breast reconstruction with or without inguinal lymph node transplant for treatment of breast cancer related arm lymphedema:
A multicenter randomized controlled trial

The aim of this study is to evaluate investigate whether BCRL will improve in patients with BCRL undergoing DIEP-flap BR combined with an inguinal lymph node transplant have statistically significant improvement of their BCRL (primary objective),…

The LYMPH Trial - Surgical versus Conservative Complex Physical Decongestion Therapy for Chronic Breast Cancer-Related Lymphedema: A Pragmatic, Randomized, Multicenter Superiority Trial

Primary Objective:The primary objective of this trial is to test whether lymphatic surgery provides better QoL (assessed with the Lymph-ICF-UL, upper limb, questionnaire) 15 months after randomization (and therefore about one year after surgery)…