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Mesalamine for Colorectal Cancer Prevention Program in Lynch syndrome

Primairy Objective* To test whether 5-ASA reduces the occurrence of colonic benign or malignant neoplasia compared to placebo in Lynch syndrome (LS) patients as detected by any colonoscopy until the end of study.Secondary Objectives* To test wheter…

A Phase III, Randomized, Double-Blind, Active Comparator-Controlled Clinical Trial, Conducted Under In-House Blinding Conditions, to Examine the Efficacy and Safety of Aprepitant for the Prevention of Chemotherapy-Induced Nausea and Vomiting (CINV) in Pediatric Patients

The purpose of this current study is to evaluate the efficacy and safety of the 3-day oral aprepitant regimen when administered concomitantly with ondansetron, with or without dexamethasone, in pediatric patients, from 6 months to 17 years of age,…

Immune effects of acidic and neutral oligosaccharides in the nutrition of preterm infants.

Investigate the effect of acidic and neutral oligosaccharides supplemented enteral nutrition on infectious morbidity, feeding tolerance and short-term outcome in VLBW infants. Furthermore, an attempt is made to elucidate the role of acidic and…

A Multicenter, Randomized, Double-blind, Placebo controlled Study of the Human Anti-TNF Monoclonal Antibody Adalimumab for the Induction of Clinical Remission in Subjects with Moderately to Severely Active Ulcerative Colitis.

To assess the efficacy and safety of adalimumab for the induction of clinical remission in subjects with moderately to severely active ulcerative colitis.

Combined intracutaneous and intraperitoneal anaesthesia for postoperative pain reduction after laparoscopic cholecystectomy

To analyse the effect of preoperative intracutaneous and intraperitoneal instillation of levobupivacaine on postoperative pain after laparoscopic cholecystectomy

Effect of the consumption of a fermented dairy product on constipation in children: a multi-centre randomized controlled trial.

To determine the clinical effect and tolerance of BA in children with functional constipation aged 3-16 years.

A Randomized, Double-Blind, Placebo-Controlled Study in Healthy Male Subjects to Evaluate the Safety, Tolerability, and Pharmacokinetics of Single Ascending Oral Doses of JNJ-26070109

JNJ-2607019 is an investigational drug being developed for gastroesophageal reflux disease (GERD) to reduce the complaints of abdominal pain and heartburn in people with this disease. JNJ-26070109 inhibits the gastrin receptor in the stomach. The…

The effects of pectin on aging-related changes in intestinal barrier function, immune function and microbial composition

This study will be don to gain insights in the effects of the dietary fiber pectin on gut functioning and the immune system. The information will gain more insights in the working mechanism of this specific dietary fiber. Further, we are especially…

A phase III, randomized, placebo-controlled clinical trial to study the efficacy and safety of MK-0517/fosaprepitant and ondansetron versus ondansetron for the prevention of chemotherapy-induced nausea and vomiting (CINV) in pediatric subjects receiving emetogenic chemotherapy

The objective of the study is to evaluate the efficacy and safety of a single dose of fosaprepitant when administered concomitantly with ondansetron, with or without dexamethasone, in subjects birth to 17 years of age receiving emetogenic…

Modulation of small intestinal microbial composition and activity, systemic immune adaptation and blood transcriptional changes induced by 2-wks consumption with 2 fermented milk products; a randomized, exploratory, cross-over, double blind, controlled study in ileostomy patients

Rationale: to determine the small intestinal microbiota response in humans to dietary interventions for two consecutive weeks, and to relate this to parameters of intestinal barrier function and immune and metabolic responses in blood, as functional…

Impact of galacto-oligosaccharides on the intestinal microbial composition and -activity: a proof of concept study

We would like to investigate whether GOS benefically alters the microbiota composition and -activity of the colon (not only faeces as done previously). This has not been done before by performing colonoscopies in a physiological condition and…

The effect of galacto-oligosaccharides on gut complaints without medical diagnosis (e.g. bloating, constipation, diarrhea) in adult women

to assess the effect of 21 days of consumption of 5.5 g GOS powder on the gut comfort component score (based on 5 questions), as compared to a control group receiving maltodextrin (control product).

A double-blind, randomized, placebo-controlled, phase 2a study to evaluate the safety, tolerability, and pharmacodynamic (PD) effects of two infusions of escalating doses of TPM502 in adults diagnosed with celiac disease (CeD)

Main objective:To evaluate the safety and tolerability of two i.v. infusions of escalating doses of TPM502 in CeD patients.Secondary objectives:• To identify PD effects consistent with the induction of antigen-specific immune tolerance following the…

Carbohydrate induced resilience of the gut microbiome after antibiotics use

The objective of this study is to investigate the potential of a dietary fiber, 2'-fucosyllactose (2'-FL), to improve gut microbiome resilience after antibiotics use.Furthermore it will also be investigated whether there is a link between…

Multicenter, semi-blinded, randomized, controlled, parallel arms clinical study on the performance of SGM-101, a fluorochrome-labeled anti-carcinoembryonic antigen (CEA) monoclonal antibody, for the delineation of primary and recurrent tumor and metastases in patients undergoing curative surgery for colorectal cancer.

The primary objective of this clinical trial is to assess the performance of SGM-101 in theintraoperative detection of resection margins and metastases in patients undergoing curativesurgery for colorectal cancer. SGM-101 will be administered as a…